Cytokines are signalling proteins generated in most part by immune cells that have critical functions in cellular lifespan. Here we present recent data on three selected anti-inflammatory cytokines: interleukin (IL)-10, IL-4 and transforming growth factor β (TGF-β). IL-10 inhibits the synthesis of major pro-inflammatory cytokines, chemokines, and mediates anti-inflammatory reactions. IL-4 is a multifunctional cytokine which plays a crucial role in the regulation of immune responses and is involved in processes associated with development and differentiation of lymphocytes and regulation of T cell survival. Transforming TGF-β, which in normal cells or pre-cancerous cells, promotes proliferation arrest which represses tumour growth. In this review, we focus on the influence of IL-10, IL-4 and TGF-β on various types of cancer as well as potential of these selected cytokines to serve as new biomarkers which can support effective therapies for cancer patients. This article is presented based on a review of the newest research results.

中文翻译：

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关于白介素4，白介素10和转化生长因子β对癌细胞的影响的科学报道。

细胞因子是信号蛋白，大部分是由免疫细胞产生的，在细胞寿命中具有关键功能。在这里，我们介绍三种选定的抗炎细胞因子的最新数据：白介素（IL）-10，IL-4和转化生长因子β（TGF-β）。IL-10抑制主要的促炎细胞因子，趋化因子的合成，并介导抗炎反应。IL-4是一种多功能细胞因子，在调节免疫反应中起关键作用，并参与与淋巴细胞发育和分化以及T细胞存活率调节相关的过程。在正常细胞或癌前细胞中转化的TGF-β可促进增殖抑制，从而抑制肿瘤的生长。在这篇评论中，我们重点介绍IL-10的影响，IL-4和TGF-β对各种类型癌症的影响以及这些选定的细胞因子作为新型生物标志物的潜力，可以为癌症患者提供有效的疗法。本文是基于对最新研究结果的回顾而提出的。