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Function of Pro-Resolving Lipid Mediator Resolvin E1 in Type 2 Diabetes.
Critical Reviews in Immunology ( IF 1.3 ) Pub Date : 2018-01-01 , DOI: 10.1615/critrevimmunol.2018026750
Corneliu Sima 1 , Bruce Paster 1 , Thomas E Van Dyke 1
Affiliation  

Programming of inflammation resolution is governed by a class of specialized pro-resolving lipid mediators (SPMs) that act in concert to modulate epithelial, endothelial, and immune cell function for restoration of homeostasis. The resolution circuits are altered in obesity and associated morbidities, including type 2 diabetes mellitus (T2D), through reduced production and/or action of SPMs, which can be rescued by therapeutic SPM delivery or up-regulation of SPM receptors. Resolvin E1 (RvE1), an eicosapentaenoic acid derivative, has potent pro-resolving and insulin-sensitizing actions mediated by BLT1 and ERV1 receptors in the vasculature and metabolic organs. Nonetheless, the RvE1-mediated increase in protective adipokines such as adiponectin in white adipose tissues, the enhancement of monocyte patrolling function in the vasculature, as well as the macrophage-clearing functions improve metabolic control in obese-prone conditions. RvE1-enhanced resolving function in obesity prevents dysbiosis of the gut microflora and increased gut permeability. These functions suggest that RE1 has therapeutic potential for immunometabolic alterations associated with T2D in patients with reduced inflammation resolving capacity. SPM profiling in individuals at risk for T2D and associated complications will help to advance personalized disease management and precision medicine.

中文翻译:

促分解脂质介质 Resolvin E1 在 2 型糖尿病中的作用。

炎症消退的编程由一类专门的促消脂脂质介质 (SPM) 控制,它们协同作用以调节上皮细胞、内皮细胞和免疫细胞功能以恢复体内平衡。通过减少 SPM 的产生和/或作用,可以通过治疗性 SPM 递送或上调 SPM 受体来挽救肥胖和相关疾病,包括 2 型糖尿病 (T2D),从而改变解决电路。Resolvin E1 (RvE1) 是一种二十碳五烯酸衍生物,具有由脉管系统和代谢器官中的 BLT1 和 ERV1 受体介导的有效促分解和胰岛素增敏作用。尽管如此,RvE1 介导的保护性脂肪因子增加,如白色脂肪组织中的脂联素,血管系统中单核细胞巡逻功能的增强,以及巨噬细胞清除功能可改善肥胖易发条件下的代谢控制。RvE1 增强的肥胖解决功能可防止肠道菌群失调和肠道通透性增加。这些功能表明 RE1 对炎症消退能力降低的患者与 T2D 相关的免疫代谢改变具有治疗潜力。对有 T2D 风险和相关并发症风险的个体进行 SPM 分析将有助于推进个性化疾病管理和精准医疗。这些功能表明 RE1 对炎症消退能力降低的患者与 T2D 相关的免疫代谢改变具有治疗潜力。对有 T2D 风险和相关并发症风险的个体进行 SPM 分析将有助于推进个性化疾病管理和精准医疗。这些功能表明 RE1 对炎症消退能力降低的患者与 T2D 相关的免疫代谢改变具有治疗潜力。对有 T2D 风险和相关并发症风险的个体进行 SPM 分析将有助于推进个性化疾病管理和精准医疗。
更新日期:2019-11-01
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