In nature, gene regulatory networks are a key mediator between the information stored in the DNA of living organisms (their genotype) and the structural and behavioral expression this finds in their bodies, surviving in the world (their phenotype). They integrate environmental signals, steer development, buffer stochasticity, and allow evolution to proceed. In engineering, modeling and implementations of artificial gene regulatory networks have been an expanding field of research and development over the past few decades. This review discusses the concept of gene regulation, describes the current state of the art in gene regulatory networks, including modeling and simulation, and reviews their use in artificial evolutionary settings. We provide evidence for the benefits of this concept in natural and the engineering domains.

中文翻译：

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人工基因调控网络——综述

在自然界中，基因调控网络是储存在生物体 DNA 中的信息（它们的基因型）与其在它们的身体中发现的结构和行为表达之间的关键中介，它们在世界上存活下来（它们的表型）。它们整合环境信号、引导发展、缓冲随机性，并允许进化继续进行。在过去的几十年里，人工基因调控网络的工程、建模和实现一直是一个不断扩大的研究和开发领域。这篇综述讨论了基因调控的概念，描述了基因调控网络的当前技术水平，包括建模和模拟，并回顾了它们在人工进化环境中的使用。我们为这个概念在自然和工程领域的好处提供了证据。