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Copper Concentrations in Breast Cancer: A Systematic Review and Meta-Analysis.
Current Medicinal Chemistry ( IF 4.1 ) Pub Date : 2020-10-31 , DOI: 10.2174/0929867326666190918120209
Leila Jouybari 1 , Faezeh Kiani 2 , Farhad Islami 3 , Akram Sanagoo 1 , Fatemeh Sayehmiri 4 , Bozena Hosnedlova 5, 6 , Monica Daniela Doşa 7 , Rene Kizek 5, 6 , Salvatore Chirumbolo 8, 9 , Geir Bjørklund 10
Affiliation  

Breast cancer is the most common neoplasm, comprising 16% of all women's cancers worldwide. Research of Copper (Cu) concentrations in various body specimens have suggested an association between Cu levels and breast cancer risks. This systematic review and meta-analysis summarize the results of published studies and examine this association. We searched the databases PubMed, Scopus, Web of Science, and Google Scholar and the reference lists of relevant publications. The Standardized Mean Differences (SMDs) between Cu levels in cancer cases and controls and corresponding Confidence Intervals (CIs), as well as I2 statistics, were calculated to examine heterogeneity.

Following the specimens used in the original studies, the Cu concentrations were examined in three subgroups: serum or plasma, breast tissue, and scalp hair. We identified 1711 relevant studies published from 1984 to 2017. There was no statistically significant difference between breast cancer cases and controls for Cu levels assayed in any studied specimen; the SMD (95% CI) was -0.01 (-1.06 - 1.03; P = 0.98) for blood or serum, 0.51 (-0.70 - 1.73; P = 0.41) for breast tissue, and -0.88 (-3.42 - 1.65; P = 0.50) for hair samples. However, the heterogeneity between studies was very high (P < 0.001) in all subgroups. We did not find evidence for publication bias (P = 0.91). The results of this meta-analysis do not support an association between Cu levels and breast cancer. However, due to high heterogeneity in the results of original studies, this conclusion needs to be confirmed by well-designed prospective studies.


中文翻译:

乳腺癌中的铜浓度:系统评价和荟萃分析。

乳腺癌是最常见的肿瘤,占全世界所有女性癌症的16%。对各种人体标本中铜(Cu)浓度的研究表明,铜含量与乳腺癌风险之间存在关联。该系统评价和荟萃分析总结了已发表研究的结果并检查了这种关联。我们搜索了PubMed,Scopus,Web of Science和Google Scholar数据库以及相关出版物的参考列表。计算癌症病例和对照中的铜水平之间的标准均值差(SMD)和相应的置信区间(CI)以及I2统计量,以检查异质性。

在原始研究中使用的标本之后,在三个亚组中检查了铜的浓度:血清或血浆,乳腺组织和头皮头发。我们确定了1984年至2017年发表的1711篇相关研究。在任何研究的样本中,乳腺癌病例与对照中的Cu水平在统计学上均无统计学差异。血液或血清SMD(95%CI)为-0.01(-1.06- 1.03; P = 0.98),乳腺组织为0.51(-0.70-1.73; P = 0.41),-0.88(-3.42-1.65; P = 0.50)的头发样本。但是,研究之间的异质性在所有亚组中都很高(P <0.001)。我们没有发现发表偏倚的证据(P = 0.91)。这项荟萃分析的结果不支持铜水平与乳腺癌之间的关联。但是,由于原始研究的结果存在高度异质性,
更新日期:2020-11-09
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