Introduction: Inovirus-associated vectors (IAVs) are derived from bacterial filamentous viruses (phages). As vaccine carriers, they have elicited both cellular and humoral responses against a variety of pathogens causing infectious diseases and other non-infectious diseases. By displaying specific antigen epitopes or proteins on their coat proteins, IAVs have merited much study, as their unique abilities are exploited for widespread vaccine development. Areas covered: The architectural traits of filamentous viruses and their derivatives, IAVs, facilitate the display of specific antigenic peptides which induce antibody production to prevent or curtail infection. Inoviruses provide a foundation for cost-efficient large-scale specific phage display. In this paper, the development of different applications of inovirus-based phage display vaccines across a broad range of pathogens and hosts is reviewed. The references cited in this review were selected from established databases based on the authors' knowledge of the study subject. Expert commentary: The importance of phage-display technology has been recently highlighted by the Nobel Prize in Chemistry 2018 awarded to George P. Smith and Sir Gregory P. Winter. Furthermore, the symbiotic nature of filamentous viruses infecting intestinal F+ E. coli strains offers an attractive platform for the development of novel vaccines that stimulate mucosal immunity.

中文翻译：

---

使用噬菌体展示技术开发与禽病毒相关的载体疫苗。

简介：猪病毒相关载体（IAV）来源于细菌丝状病毒（噬菌体）。作为疫苗载体，它们引起了引起感染性疾病和其他非感染性疾病的多种病原体的细胞和体液反应。通过在其外壳蛋白上显示特定的抗原表位或蛋白质，IAV值得进行大量研究，因为其独特的功能已被广泛用于疫苗开发。覆盖区域：丝状病毒及其衍生物IAV的结构特征有助于展示特定的抗原肽，这些抗原肽可诱导抗体产生以预防或减少感染。禽病毒为经济高效的大规模特定噬菌体展示提供了基础。在本文中，综述了基于猪病毒的噬菌体展示疫苗在多种病原体和宿主中的不同应用的开发。本综述中引用的参考文献是根据作者对研究主题的了解从已建立的数据库中选择的。专家评论：噬菌体展示技术的重要性最近被授予乔治·P·史密斯和格里高利·P·温特爵士的2018年诺贝尔化学奖所强调。此外，感染肠道F +大肠杆菌菌株的丝状病毒的共生特性为开发刺激粘膜免疫的新型疫苗提供了诱人的平台。专家评论：噬菌体展示技术的重要性最近被授予乔治·P·史密斯和格里高利·P·温特爵士的2018年诺贝尔化学奖所强调。此外，感染肠道F +大肠杆菌菌株的丝状病毒的共生特性为开发刺激粘膜免疫的新型疫苗提供了诱人的平台。专家评论：噬菌体展示技术的重要性最近被授予乔治·P·史密斯和格里高利·P·温特爵士的2018年诺贝尔化学奖所强调。此外，感染肠道F +大肠杆菌菌株的丝状病毒的共生特性为开发刺激粘膜免疫的新型疫苗提供了诱人的平台。