The serotonergic system is implicated in the neurobiological control of learning and memory, both in healthy individuals and pathological disorders, although the underlying mechanisms remain elusive. After the cloning and characterization of serotonin, or 5-hydroxytryptamine (5-HT), receptors and the resultant development of selective agonist and antagonist compounds and transgenic receptor-knockout mice, our understanding of the role of various serotonin receptors in learning and memory has improved. 5-HT(1A), 5-HT4 and 5-HT6 receptors are densely expressed in brain regions innervated by serotonergic projections from the raphe nuclei and are associated with learning and memory. Here, we review the evidence that compounds acting on these receptors can have positive effects on learning and memory, and we discuss the potential mechanisms involved. This information raises the possibility that such compounds could be developed as adjunct therapeutics with existing treatments to improve learning and memory deficits, which are core symptoms of Alzheimer's disease, schizophrenia and depression.

中文翻译：

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5-HT（1A），5-HT4和5-HT6受体在学习和记忆中的作用。

血清素能系统与健康个体和病理性疾病的学习和记忆的神经生物学控制有关，尽管其潜在机制尚不清楚。在血清素或5-羟色胺（5-HT）受体的克隆和鉴定以及选择性激动剂和拮抗剂化合物以及转基因受体敲除小鼠的发展之后，我们对各种血清素受体在学习和记忆中的作用有了了解改善。5-HT（1A），5-HT4和5-HT6受体在由缝核的血清素能投射支配的大脑区域中密集表达，并且与学习和记忆有关。在这里，我们回顾了作用于这些受体的化合物可对学习和记忆产生积极影响的证据，并讨论了其中涉及的潜在机制。