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Diagnostic Approach and Management of Lynch Syndrome (Hereditary Nonpolyposis Colorectal Carcinoma): A Guide for Clinicians
CA: A Cancer Journal for Clinicians ( IF 254.7 ) Pub Date : 2006-07-01 , DOI: 10.3322/canjclin.56.4.213
Yvonne M C Hendriks 1 , Andrea E de Jong , Hans Morreau , Carli M J Tops , Hans F Vasen , Juul Th Wijnen , Martijn H Breuning , Annette H J T Bröcker-Vriends
Affiliation  

The patient with a family history for colorectal carcinoma constitutes a complicated diagnostic challenge involving many clinicians. The diagnostic workup of familial colorectal cancer is an elaborate and time consuming process in which the family and several medical specialists closely collaborate. However, establishing a diagnosis can be very rewarding. If a mutation is detected in the family, a satisfactory explanation can be provided for an accumulation of tumors at young age, and often of untimely death. Appropriate presymptomatic testing can be offered to reduce mortality among at‐risk family members, and relatives not at risk can avoid uncertainty and needlessly intensive surveillance.

中文翻译:

Lynch 综合征(遗传性非息肉病性结直肠癌)的诊断方法和管理:临床医生指南

具有结直肠癌家族史的患者构成了涉及许多临床医生的复杂诊断挑战。家族性结直肠癌的诊断检查是一个复杂且耗时的过程,需要家人和几位医学专家密切合作。然而,建立诊断是非常有益的。如果在家庭中检测到突变,则可以为年轻时肿瘤的积累以及通常过早死亡提供令人满意的解释。可以提供适当的症状前检测以降低有风险的家庭成员的死亡率,而没有风险的亲属可以避免不确定性和不必要的密集监测。
更新日期:2006-07-01
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