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The Genetics and Epigenetics of Sex Change in Fish.
Annual Review of Animal Biosciences ( IF 12.0 ) Pub Date : 2020-02-18 , DOI: 10.1146/annurev-animal-021419-083634
Oscar Ortega-Recalde , Alexander Goikoetxea , Timothy A Hore , Erica V Todd , Neil J Gemmell

Fish show extraordinary sexual plasticity, changing sex naturally as part of their life cycle or reversing sex because of environmental stressors. This plasticity shows that sexual fate is not an irreversible process but the result of an ongoing tug-of-war for supremacy between male and female signaling networks. The behavioral, gonadal, and morphological changes involved in this process are well described, yet the molecular events that underpin those changes remain poorly understood. Epigenetic modifications emerge as a critical link between environmental stimuli, the onset of sex change, and subsequent maintenance of sexual phenotype. Here we synthesize current knowledge of sex change, focusing on the genetic and epigenetic processes that are likely involved in the initiation and regulation of sex change. We anticipate that better understanding of sex change in fish will shed new light on sex determination and development in vertebrates and on how environmental perturbations affect sexual fate.

中文翻译:


鱼类性别变化的遗传学和表观遗传学。

鱼表现出非凡的性可塑性,在其生命周期中自然改变性,或者由于环境压力而逆转性。这种可塑性表明,性命不是一个不可逆转的过程,而是持续不断的男女信号网络至高无上的拔河比赛的结果。很好地描述了此过程中涉及的行为,性腺和形态变化,但对这些变化基础的分子事件知之甚少。表观遗传修饰是环境刺激,性别变化的发作和随后的性表型维持之间的关键链接。在这里,我们综合了有关性别变化的当前知识,重点关注可能与性别变化的引发和调控有关的遗传和表观遗传过程。

更新日期:2020-02-18
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