OBJECTIVE We aimed to evaluate the sensitivity of fine needle aspiration (FNA) for the diagnosis of Hodgkin's lymphoma (HL) in HIV-infected patients. STUDY DESIGN An electronic search was conducted to retrospectively identify patients diagnosed with HL who underwent FNA followed by confirmatory biopsy. FNAs were categorized as negative, atypical/suspicious/positive, or nondiagnostic. Diagnostic sensitivity in HIV+ and HIV- patients was statistically compared via Fisher's exact test, with a p value <0.05 considered significant. RESULTS Thirty-six patients meeting inclusion criteria were identified (24 HIV- and 12 HIV+). Average age was 36.0 ± 11.5 and 36.5 ± 7.4 years (means ± SD) in HIV- and HIV+ patients, respectively. The male-to-female ratio was 1.4:1 in HIV- patients versus 3:1 in HIV+ patients. Among these 36 patients, a total of 42 FNAs were performed. Overall sensitivity of FNA was 66.7% (95% confidence interval: 52.4-80.9%). When stratified by HIV status, a statistically significant difference in FNA sensitivity was detected, as sen-sitivity was 84.6% (70.8-98.4%) in HIV- patients versus only 37.5% (13.8-61.2%) in HIV+ patients (p =0.003). CONCLUSION The diagnostic sensitivity of FNA biopsy was significantly attenuated in the HIV+ cohort. In HIV-infected patients presenting with lymphadenopathy, increased clinical suspicion of HL is critical to avoid misdiagnosis.

中文翻译：

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人类免疫缺陷病毒感染患者的细针穿刺活检对霍奇金淋巴瘤的细胞诊断敏感性降低。

目的我们旨在评估细针穿刺术（FNA）对HIV感染患者诊断霍奇金淋巴瘤（HL）的敏感性。研究设计进行电子搜索以回顾性鉴定经FNA确诊活检的确诊为HL的患者。FNA分类为阴性，非典型/可疑/阳性或无法诊断。通过Fisher精确检验对HIV +和HIV-患者的诊断敏感性进行统计学比较，p值<0.05被认为是显着的。结果确定了36例符合入选标准的患者（24例HIV-和12例HIV +）。HIV和HIV +患者的平均年龄分别为36.0±11.5岁和36.5±7.4岁（平均数±SD）。HIV-患者的男女比例为1.4：1，而HIV +患者为3：1。在这36名患者中，总共进行了42次FNA。FNA的总体敏感性为66.7％（95％置信区间：52.4-80.9％）。当按HIV状况分层时，检测到FNA敏感性有统计学上的显着差异，因为HIV患者的敏感性为84.6％（70.8-98.4％），而HIV +患者仅为37.5％（13.8-61.2％）（p = 0.003 ）。结论在HIV +人群中，FNA活检的诊断敏感性显着降低。在存在淋巴结病的HIV感染患者中，增加对HL的临床怀疑对于避免误诊至关重要。2％）在HIV +患者中（p = 0.003）。结论在HIV +人群中，FNA活检的诊断敏感性显着降低。在存在淋巴结病的HIV感染患者中，增加对HL的临床怀疑对于避免误诊至关重要。2％）在HIV +患者中（p = 0.003）。结论在HIV +人群中，FNA活检的诊断敏感性显着降低。在存在淋巴结病的HIV感染患者中，增加对HL的临床怀疑对于避免误诊至关重要。