Over the past 20 years 3,4-methylenedioxymethamphetamine (MDMA; also known as 'ecstasy') has become a widely used recreational drug of abuse. However, studies have indicated that it is neurotoxic to serotonergic nerve terminals in rats and non-human primates and dopaminergic nerve terminals in mice. Recently, this tenet has been questioned following a study suggesting that MDMA can cause toxicity to dopamine-containing neurons in monkeys. In this article, the factors contributing to this change in neurotoxic profile are discussed.

中文翻译：

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对于含有多巴胺的神经元，经常用摇头丸给药是危险的吗？

在过去的20年中，3,4-亚甲二氧基甲基苯丙胺（MDMA；也称为“摇头丸”）已成为一种广泛使用的娱乐性滥用药物。然而，研究表明，它对大鼠的血清素能神经末梢和小鼠的非人灵长类和多巴胺能神经末梢具有神经毒性。最近，在一项研究表明MDMA可以对猴子的含多巴胺的神经元产生毒性之后，对该原则提出了质疑。在本文中，讨论了导致神经毒性特征改变的因素。