OBJECTIVE To examine the association among body composition, defined as the percentage of body fat mass (BF) and lean mass (LM), bone mineral content (BMC) and bone mineral density (BMD) in the human body and the presentation of symptoms (i.e., fatigue, pain, depression, anxiety, and poor sleep quality) in persons with multiple sclerosis (MS). DESIGN The present study is a secondary analysis of baseline data from a physical activity intervention for persons with MS. The research question was informed by the theory of unpleasant symptoms, namely an examination of the relationship between body composition (i.e., physiologic antecedent) and symptoms in this sample of 77 participants with MS. The association between body composition and symptoms was examined using partial correlation analyses controlling for age, sex, and disability status. RESULTS Participants were 49 ± 9 years of age on average and diagnosed with MS for an average of 12 ± 8 years. Most participants identified as female (74%), reported having a relapsing-remitting disease course (78%), and moderate MS-related disability based on a median (interquartile range) Patient Determined Disease Steps score of 3.0 (3.0). Partial correlation analyses indicate there were no significant correlations observed among body composition (%BF, %LM, BMC, and BMD) and any symptoms (fatigue, pain, depression, anxiety, and sleep quality). CONCLUSION Additional research that examines other physiologic factors as well as psychological and situational factors based on the theory of unpleasant symptoms that might account for symptoms in persons with MS is necessary. This will inform behavioral interventions and rehabilitation programs that target theory-based factors such as correlates of symptoms in MS. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

中文翻译：

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没有证据表明多发性硬化症患者的身体成分和症状之间存在关联。

目的检查身体成分之间的关​​联，身体成分定义为人体脂肪量 (BF) 和瘦体重 (LM) 的百分比、骨矿物质含量 (BMC) 和骨矿物质密度 (BMD) 与症状表现之间的关系。多发性硬化症 (MS) 患者的疲劳、疼痛、抑郁、焦虑和睡眠质量差）。设计 本研究是对 MS 患者身体活动干预基线数据的二次分析。研究问题是根据不愉快症状理论提出的，即检查身体成分（即生理前因）与 77 名 MS 参与者样本中的症状之间的关系。使用控制年龄、性别和残疾状态的偏相关分析来检查身体成分和症状之间的关联。结果 参与者的平均年龄为 49 ± 9 岁，被诊断患有 MS 的时间平均为 12 ± 8 年。大多数参与者被确定为女性 (74%)，报告患有复发-缓解病程 (78%)，并且根据患者确定的疾病步骤的中位数（四分位距）评分为 3.0 (3.0)，患有中度 MS 相关残疾。偏相关分析表明，在身体成分（%BF、%LM、BMC 和 BMD）与任何症状（疲劳、疼痛、抑郁、焦虑和睡眠质量）之间没有观察到显着相关性。结论 根据可能导致 MS 患者症状的不愉快症状理论，进一步研究检查其他生理因素以及心理和情境因素是必要的。这将为针对基于理论的因素（例如 MS 症状的相关性）的行为干预和康复计划提供信息。（PsycINFO 数据库记录 (c) 2019 APA，保留所有权利）。