Plant natural products have been an attracting platform for the isolation of various active drugs and other bioactives. However large-scale extraction of these compounds is affected by the difficulty in mass cultivation of these plants and absence of strategies for successful extraction. Even though, synthesis by chemical method is an alternative method; it is less efficient as their chemical structure is highly complex which involve enantio-selectivity. Thus an alternate bio-system for heterologous production of plant natural products using microbes has emerged. Advent of various omics, synthetic and metabolic engineering strategies revolutionised the field of heterologous plant metabolite production. In this context, various engineering methods taken to synthesise plant natural products are described with an additional focus to fermentation strategies.

中文翻译：

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定制微生物以生产高价值植物来源的化合物：从途径工程到发酵生产。

植物天然产物一直是分离各种活性药物和其他生物活性物质的诱人平台。然而，这些化合物的大规模提取受到这些植物大规模栽培的困难以及缺乏成功提取策略的影响。即使通过化学方法合成是另一种方法。它的化学结构非常复杂，涉及对映选择性，因此效率较低。因此，已经出现了使用微生物异源生产植物天然产物的替代生物系统。各种组学，合成和代谢工程策略的出现彻底改变了异源植物代谢产物的生产领域。在这种情况下，