Stem cell transplantation is a new therapeutic strategy in the treatment of neurodegenerative disorders such as Parkinson's disease (PD). Therefore, in this study, the therapeutic effects of Trabecular Meshwork Mesenchymal Stem Cells (TM-MSCs) transplantation, as a new source of mesenchymal stem cells, were evaluated in the animal model of PD.

After the development and confirmation of hemi-parkinsonian rats by administration of 6-hydroxy dopamine (6-OHDA) and apomorphine-induced rotation test, green fluorescent protein (GFP) labeled TM-MSCs (normal and induced cells) were transplanted in the striatum of rats. Next, the rotation test, rotarod test, open field, passive avoidance memory tests and immunohistochemistry for tyrosine hydroxylase (TH) were done.

The results showed that the number of turns significantly decreased and the improvement of motor performance was achieved after cell transplantation. However, there was no significant difference in passive avoidance memory of animals documented by shuttle box test. The number of GFP- labeled cells expressing TH significantly is increased compared to the vehicle group.

Collectively, it seems that TM-MSCs and induced TM-MSCs cell transplantation have positive effects on some aspects of the animal model of PD. Other studies may reveal the potentially positive aspects of these cells in the laboratory and clinical studies.

干细胞移植是治疗神经退行性疾病如帕金森氏病（PD）的一种新的治疗策略。因此，在这项研究中，在PD动物模型中评估了小梁网间充质干细胞（TM-MSC）移植作为间充质干细胞的新来源的治疗效果。

在通过施用6-羟基多巴胺（6-OHDA）和阿扑吗啡诱导的旋转试验确定并确认了半帕金森病大鼠后，将绿色荧光蛋白（GFP）标记的TM-MSC（正常细胞和诱导细胞）移植到纹状体中大鼠。接下来，进行了酪氨酸羟化酶（TH）的旋转测试，旋转棒测试，开放视野，被动回避记忆测试和免疫组织化学。

结果表明，细胞移植后匝数显着减少，运动性能得到改善。然而，穿梭箱试验证明动物的被动回避记忆没有显着差异。与载体组相比，表达TH的GFP标记的细胞的数量显着增加。

总的来说，似乎TM-MSC和诱导的TM-MSCs细胞移植对PD动物模型的某些方面具有积极作用。其他研究可能会在实验室和临床研究中揭示这些细胞的潜在积极方面。