The chemokine system, which controls leukocyte trafficking, provides several potentially very attractive anti-inflammatory drug targets. However, the complexity and redundancy of this system makes it very difficult to exploit through classical drug discovery. Despite this, viruses have millions of years of experience in manipulating this system. For example, virally encoded "biopharmaceuticals"--chemokines and chemokine binding proteins--demonstrate the effectiveness of blocking a carefully selected group of chemokine receptors and how the local immune response can be changed from one dominated by Th1 cells to one dominated by Th2 cells by targeting specific chemokine receptors. The crucial importance of the binding of chemokines to glycosaminoglycans to produce their effects is also highlighted by viruses that produce binding proteins to disrupt the gradient of chemokines, which guides the direction leukocyte migration.

中文翻译：

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趋化因子调节药物的病毒先导。

控制白细胞运输的趋化因子系统提供了几种潜在的非常有吸引力的抗炎药物靶标。但是，该系统的复杂性和冗余性使其很难通过经典药物发现加以利用。尽管如此，病毒还是拥有数百万年的操纵该系统的经验。例如，病毒编码的“生物药物”（趋化因子和趋化因子结合蛋白）证明了阻断一组精心选择的趋化因子受体的有效性，以及如何将局部免疫反应从一种以Th1细胞为主的细胞转变为以Th2细胞为主的细胞。通过靶向特定的趋化因子受体。