Many novel anti-inflammatory compounds have been derived from research tools designed to better understand the complex process of leukocyte extravasation at sites of inflammation. Given that selectin-mediated rolling is the crucial initial step of leukocyte localization to the skin, specific interference with this mechanism is a particularly attractive target to treat cutaneous inflammation. Recently, several exciting advances have been reported aimed at selective interference with specific target molecules crucially involved in leukocyte rolling.

中文翻译：

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干扰白细胞滚动-一种炎性皮肤疾病的有前途的治疗方法吗？

许多新颖的抗炎化合物已从旨在更好地了解炎症部位白细胞外渗的复杂过程的研究工具中衍生出来。鉴于选择素介导的滚动是白细胞定位于皮肤的关键初始步骤，因此对该机制的特异性干扰是治疗皮肤炎症的特别有吸引力的目标。近来，已经报道了一些激动人心的进展，其旨在选择性干扰关键地参与白细胞滚动的特定靶分子。