Endothelial cells, which are situated at the interface between blood and the vessel wall, have a crucial role in controlling vascular tone and homeostasis, particularly in determining the expression of pro-atherosclerotic and anti-atherosclerotic genes. Many of these effects are mediated by changes in the generation and release of endothelium-derived autacoids [from the Greek autos (self) and akos (remedy)], which are generally short-lived and locally acting. In vivo, endothelial cells are constantly subjected to mechanical stimulation, which in turn determines the acute production of autacoids and the levels of autacoid-producing enzymes.

中文翻译：

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通过血液动力调节内皮源性血管活性autacoid产生。

位于血液和血管壁之间的界面的内皮细胞在控制血管张力和体内平衡，特别是在确定动脉粥样硬化和抗动脉粥样硬化基因的表达方面起着至关重要的作用。这些作用中的许多是由内皮衍生的自噬菌体的产生和释放的变化所介导的（来自希腊汽车（自身）和akos（药物）），它们通常是短暂的且在局部起作用。在体内，内皮细胞不断受到机械刺激，这又决定了autacoids的急性产生和autacoid产生酶的水平。