Nervous system injury represent the most common injury and was unique clinical challenge. Using of growth factors (GFs) for the treatment of nervous system injury showed effectiveness in halting its process. However, simple application of GFs could not achieve high efficacy because of its rapid diffusion into body fluids and lost from the lesion site. The drug delivery systems (DDSs) construction used to deliver GFs were investigated so that they could surmount its rapid diffusion and retain at the injury site. This study summarizes commonly used DDSs for sustained release of GFs that provide neuroprotection or restoration effects for nervous system injury.

神经系统损伤是最常见的损伤，是独特的临床挑战。使用生长因子（GFs）治疗神经系统损伤显示出有效的中止过程。但是，由于GFs快速扩散到体液中并从病变部位丢失，因此简单应用GFs并不能达到很高的疗效。对用于递送GF的药物递送系统（DDS）的构造进行了研究，以使它们可以克服其快速扩散并保留在损伤部位。这项研究总结了持续释放GF的常用DDS，这些DDS为神经系统损伤提供神经保护或恢复作用。