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Nasal colonization of methicillin resistant Staphylococcus aureus in Ethiopia: a systematic review and meta-analysis.
Annals of Clinical Microbiology and Antimicrobials ( IF 5.7 ) Pub Date : 2019-09-05 , DOI: 10.1186/s12941-019-0324-y
Alemayehu Reta 1 , Abeba Mengist 1 , Asnakew Tesfahun 1
Affiliation  

BACKGROUND Methicillin-resistant Staphylococcus aureus (MRSA) is one of a medically important Gram-positive bacteria, which can be harboured majorly in the nasal cavity. Risk of consequent infection in a person colonized with S. aureus as well as MRSA upsurges with time and remains insistently increased. Hence, the objective of this meta-analysis was to determine the prevalence of S. aureus and MRSA nasal colonization in Ethiopia at large. METHODS PubMed, Google Scholar, Embase, Hinari, Sci Hub, Scopus, and the Directory of Open Access Journals were searched and a total of 10 studies have been selected for meta-analysis. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used for the literature search strategy, selection of publications, data extraction, and the reporting of results for the review. All statistical analyses were performed using STATA version 11 software via random effects model. The pooled prevalence was presented in forest plots and figure with 95% CI. RESULTS A total of ten studies with 2495 nasal swab samples were included in this meta-analysis, and the overall pooled estimated prevalence of S. aureus and MRSA nasal colonization in Ethiopia were 30.90% [95% CI 21.81-39.99%], 10.94% [95% CI 8.13-13.75%] respectively. Subgroup analysis was also noted in different regions of Ethiopia, henceforth Oromia region ranked first 21.28% [95% CI 8.22-34.35%], followed by Amhara region 6.78% [95% CI 3.02-10.54%], whereas relatively low magnitude of MRSA colonization was demonstrated from Tigray region 4.82% [95% CI 2.18-7.45%]. CONCLUSION The analysis showed that the overall prevalence of S. aureus and MRSA nasal colonization in Ethiopia were comparable with the global prevalence. But a huge variation between the regions, so the Ministry of Health of Ethiopia should design appropriate decolonization program that can address the specific regional groups as well as the national population.

中文翻译:

埃塞俄比亚耐甲氧西林金黄色葡萄球菌的鼻部定植:系统评价和荟萃分析。

背景技术耐甲氧西林的金黄色葡萄球菌(MRSA)是医学上重要的革兰氏阳性细菌之一,其可主要存在于鼻腔中。随着时间的流逝,金黄色葡萄球菌定植者以及MRSA激增的人继发感染的风险不断增加。因此,这项荟萃分析的目的是确定整个埃塞俄比亚的金黄色葡萄球菌和MRSA鼻部定植的患病率。方法检索PubMed,Google Scholar,Embase,Hinari,Sci Hub,Scopus和开放获取期刊目录,共选择了10项研究进行荟萃分析。系统评价和荟萃分析的首选报告项目(PRISMA)指南用于文献检索策略,出版物的选择,数据提取以及评价结果的报告。所有统计分析均通过随机效应模型使用STATA 11版软件进行。合并流行率以森林地块和95%CI的图表示。结果这项荟萃分析共包括10项研究,共2495份鼻拭子样本,埃塞俄比亚的金黄色葡萄球菌和MRSA鼻定植总体合并患病率分别为30.90%[95%CI 21.81-39.99%],10.94%分别为[95%CI 8.13-13.75%]。在埃塞俄比亚的不同地区也进行了亚组分析,此后,奥罗米亚地区排名第一,为21.28%[95%CI 8.22-34.35%],其次是阿姆哈拉地区6.78%[95%CI 3.02-10.54%],而MRSA的幅度相对较低Tigray地区的菌落定植率为4.82%[95%CI 2.18-7.45%]。结论分析表明S的总体患病率。埃塞俄比亚的金黄色葡萄球菌和MRSA鼻腔定植与全球患病率相当。但是不同地区之间的差异很大,因此埃塞俄比亚卫生部应设计适当的非殖民化计划,以解决特定区域群体以及全国人口的需求。
更新日期:2020-04-22
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