The hydroxamate class of compounds is well known for its pharmacological applications, especially in the context of chelation therapy. In this work we investigate the performance of the fungal hydroxamates pyridoxatin (PYR), desferriastechrome (DAC) and desferricoprogen (DCO) as mitigators of stress caused by iron overload (IO) both in buffered medium and in cells. Desferrioxamine (DFO), the gold standard for IO treatment, was used as comparison. It was observed that all the fungal chelators (in aqueous medium) or PYR and DAC (in cells) are powerful iron scavengers. However only PYR and DCO (in aqueous medium) or PYR (in cells) were also antioxidant against two forms of iron-dependent oxidative stress (ascorbate or peroxide oxidation). These findings reveal that PYR is an interesting alternative to DFO for iron chelation therapy, since it has the advantage of being cell permeable and thus potentially orally active.

中文翻译：

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基于异羟肟酸酯的真菌铁螯合剂吡ido菌素，去铁血色素和去铁原蛋白的抗氧化活性和细胞摄取。

异羟肟酸酯类化合物的药理学应用是众所周知的，尤其是在螯合疗法方面。在这项工作中，我们研究了在缓冲液和细胞中，真菌异羟肟酸酯吡xxatin（PYR），去铁血色素（DAC）和去铁前体素（DCO）缓解铁过载（IO）引起的应激的性能。IO处理的黄金标准去铁胺（DFO）用作比较。据观察，所有真菌螯合剂（在水性介质中）或PYR和DAC（在细胞中）都是强力的铁清除剂。但是，只有PYR和DCO（在水性介质中）或PYR（在细胞中）也是抗两种形式的铁依赖性氧化应激（抗坏血酸或过氧化物氧化）的抗氧化剂。这些发现表明，对于铁螯合疗法，PYR是DFO的有趣替代品，