Virus-induced diseases or neurological complications are huge socio-economic burden to human health globally. The complexity of viral-mediated CNS pathology is exacerbated by reemergence of new pathogenic neurotropic viruses of high public relevance. Although the central nervous system is considered as an immune privileged organ and is mainly protected by barrier system, there are a vast majority of neurotropic viruses capable of gaining access and cause diseases. Despite continued growth of the patient population and a number of treatment strategies, there is no successful viral specific therapy available for viral induced CNS diseases. Therefore, there is an urgent need for a clear alternative treatment strategy that can effectively target neurotropic viruses of DNA or RNA genome. To address this need, rapidly growing gene editing technology based on CRISPR/Cas9, provides unprecedented control over viral genome editing and will be an effective, highly specific and versatile tool for targeting CNS viral infection. In this review, we discuss the application of this system to control CNS viral infection and associated neurological disorders and future prospects.

CRISPR/Cas9 technology as agent control over CNS viral infection.

中文翻译：

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CRISPR Cas9在中枢神经系统传染病中的广泛应用。

病毒引起的疾病或神经系统并发症是全球人类健康的巨大社会经济负担。病毒介导的中枢神经系统病理学的复杂性因与公众高度相关的新型致病性嗜神经性病毒的出现而加剧。尽管中枢神经系统被认为是具有免疫特权的器官，并且主要受到屏障系统的保护，但是绝大多数的嗜神经性病毒能够进入并导致疾病。尽管患者人数持续增长并且有许多治疗策略，但尚无针对病毒性中枢神经系统疾病的成功的病毒特异性疗法。因此，迫切需要一种可以有效地靶向DNA或RNA基因组的嗜神经病毒的明确替代治疗策略。为了解决这个需求，基于CRISPR / Cas9的快速增长的基因编辑技术，提供了对病毒基因组编辑的空前控制，将成为靶向CNS病毒感染的有效，高度特异性和多功能的工具。在这篇综述中，我们讨论了该系统在控制中枢神经系统病毒感染和相关神经系统疾病中的应用以及未来前景。

CRISPR / Cas9技术可控制CNS病毒感染。