Nanocrystals and lipid-based nanosystems have the potential to play a crucial role in a significant shift in the treatment of ophthalmic diseases. These drug delivery systems allow overcoming the barriers imposed by anatomy and physiology of the organ of vision. This review aims to present new perspectives for these innovative preparations, emphasising the applications of the nanocrystal and lipid-based nanosystem while outlining their advantages and the drawbacks. The in vivo performance of the lipid-based nanosystems was highlighted. Lipid-based nanosystems and nanocrystals showed a prolonged effect, improved ocular bioavailability, upper therapeutic efficacy, higher permeation, prolonged residence time, and sustained drug release, compared to the current applications. Well-established and innovative developments updates of these systems are highlighted herein.

中文翻译：

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眼科制剂的进展：药物纳米晶体和基于脂质的纳米系统的作用。

纳米晶体和基于脂质的纳米系统有可能在眼科疾病治疗的重大转变中发挥关键作用。这些药物递送系统允许克服视觉器官的解剖学和生理学所施加的障碍。本综述旨在为这些创新制剂提供新的视角，强调纳米晶体和基于脂质的纳米系统的应用，同时概述它们的优缺点。突出了基于脂质的纳米系统的体内性能。与目前的应用相比，基于脂质的纳米系统和纳米晶体显示出延长的效果、改善的眼部生物利用度、更高的治疗效果、更高的渗透性、延长的停留时间和持续的药物释放。