Depression is one of the most frequently diagnosed condition in psychiatry. Despite the availability of many preparations, over 30% of treated patients do not achieve remission. Recently the emphasis is put on the contribution of the body's inflammatory response as one of the causes of depression. The interactions between nervous and immune systems are the main issue addressed by psychoneuroimmunology. In patients suffering from depression changes in the plasma concentrations of cytokines and in the number and level of activation of immune cells has been found. Attention is paid to the high levels of pro-inflammatory cytokines, the prevalence of Th1 responses to Th2, weakening of NK cell cytotoxicity and changes in lymphocyte proliferation and apoptosis. A number of studies focus on influence of antidepressants and non-standard methods of depression treatment, such as ketamine infusion, on patients' immunology. Many of them seem to regulate the immune responses. The study results encourage to look for new ways to treat depression with immunomodulatory drugs. In this article authors present the current knowledge about immune system changes accompanying depression as well as the study results showing the influence of drugs on the immune system, especially in the context of reducing the symptoms of depression.

中文翻译：

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抗抑郁药对免疫系统的影响。

抑郁症是精神病学中最常见的疾病之一。尽管有许多制剂可用，但超过30％的治疗患者仍未达到缓解。最近，人们把重点放在身体的炎症反应作为抑郁症的原因之一。神经和免疫系统之间的相互作用是心理神经免疫学解决的主要问题。在患有抑郁症的患者中，已经发现血浆中细胞因子的浓度以及免疫细胞激活的数量和水平的变化。应注意高水平的促炎细胞因子，Th1对Th2的反应的普遍性，NK细胞杀伤力的减弱以及淋巴细胞增殖和凋亡的改变。许多研究集中于抗抑郁药和非标准抑郁症治疗方法（如氯胺酮输注）对患者免疫学的影响。它们中的许多似乎调节免疫反应。研究结果鼓励寻找使用免疫调节药物治疗抑郁症的新方法。本文作者介绍了有关抑郁症伴随的免疫系统变化的最新知识，以及研究结果显示了药物对免疫系统的影响，特别是在减轻抑郁症状的情况下。