Dear Editor, We thank Dr. Poddighe for his interest in our article entitled “HLA‐DQ2 homozygosis increases tTGA levels at diagnosis but does not influence the clinical phenotype of coeliac disease: A multicentre study” (Bajor, Szakács, Juhász, et al., 2019) published in the International Journal of Immunogenetics and appreciate his comments. We agree with Dr. Poddighe's comments on HLA terminol‐ ogy. Though, the HLA‐DQ2 molecule consists of α and β chains, the role of a second α chain seems to be less important in deter‐ mining the risk of the disease (van Belzen et al., 2004). The num‐ ber of HLA DQB1*0201 copies might have the most important consequences in disease pathogenesis, though it should be noted

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回复给编辑的信：HLA-DQB1*02 等位基因与乳糜泻易感性的相关性

尊敬的编辑，我们感谢 Poddighe 博士对我们题为“HLA-DQ2 纯合子在诊断时增加 tTGA 水平但不影响乳糜泻的临床表型：一项多中心研究”（Bajor、Szakács、Juhász 等人）的文章感兴趣。 , 2019) 发表在国际免疫遗传学杂志上并感谢他的评论。我们同意 Poddighe 博士对 HLA 术语的评论。尽管 HLA-DQ2 分子由 α 和 β 链组成，但第二条 α 链在确定疾病风险方面的作用似乎不太重要（van Belzen 等，2004）。HLA DQB1*0201 拷贝的数量可能对疾病的发病机制产生最重要的影响，但应该注意的是