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A genetic profile of bovine pestiviruses circulating in Brazil (1998–2018)
Animal Health Research Reviews ( IF 2.5 ) Pub Date : 2019-01-26 , DOI: 10.1017/s1466252318000130
E F Flores 1 , J F Cargnelutti 1 , F L Monteiro 1 , F V Bauermann 2 , J F Ridpath 3 , R Weiblen 1
Affiliation  

The pestiviruses bovine viral diarrhea virus 1 (BVDV-1), 2 (BVDV-2), and HoBi-like (HoBiPeV) are endemic among Brazilian cattle, the world's largest commercial bovine herd. In the last two decades (1998–2018) over 300 bovine pestiviruses have been partially or fully sequenced in Brazil, including viruses from different regions, different epidemiological backgrounds, and associated with diverse clinical presentations. Phylogenetic analysis of these viruses demonstrated a predominance of BVDV-1 (54.4%), with subgenotypes −1a (33.9% of total) and −1b (16.3%) being more frequent and subgenotypes −1d, −1e, and −1i at very low frequencies. The overall BVDV-2 frequency was 25.7% but it varied largely by region, reaching up to 48% in Southern states. BVDV-2b was the predominant subgenotype (84.8% of BVDV-2), followed by BVDV-2a (8.86%). HoBiPeV accounted for 19.9% (61/307) of the genotyped viruses and were detected at high frequency in cattle from Northeastern states. These findings demonstrate a unique mix of pestivirus species and subgenotypes, unlike that seen in Europe or North America. The design of effective diagnostic tools, vaccines, and control programs for limiting bovine pestivirus infections in Brazil must take into consideration this unique mix of viruses. This article provides a critical review of two decades of genetic identification of pestiviruses in Brazil.

中文翻译:

巴西流行的牛瘟病毒基因图谱(1998-2018)

瘟病毒牛病毒性腹泻病毒 1 (BVDV-1)、2 (BVDV-2) 和 HoBi 样 (HoBiPeV) 在巴西牛中流行,巴西牛是世界上最大的商业牛群。在过去的二十年(1998-2018 年),巴西已对 300 多种牛瘟病毒进行了部分或全部测序,包括来自不同地区、不同流行病学背景并与不同临床表现相关的病毒。这些病毒的系统发育分析显示 BVDV-1 占优势(54.4%),亚基因型 -1a(占总数的 33.9%)和 -1b(16.3%)更常见,亚基因型 -1d、-1e 和 -1i 在非常低频。BVDV-2 的总体频率为 25.7%,但因地区而异,在南部各州高达 48%。BVDV-2b 是主要的亚基因型(占 BVDV-2 的 84.8%),其次是 BVDV-2a(8.86%)。HoBiPeV 占基因分型病毒的 19.9% (61/307),并在东北各州的牛中高频率检测到。这些发现证明了瘟病毒种类和亚基因型的独特组合,这与在欧洲或北美看到的不同。在巴西设计用于限制牛瘟病毒感染的有效诊断工具、疫苗和控制计划时,必须考虑到这种独特的病毒组合。本文对巴西过去 20 年的瘟病毒基因鉴定进行了批判性回顾。巴西限制牛瘟病毒感染的控制计划必须考虑到这种独特的病毒组合。本文对巴西过去 20 年的瘟病毒基因鉴定进行了批判性回顾。巴西限制牛瘟病毒感染的控制计划必须考虑到这种独特的病毒组合。本文对巴西过去 20 年的瘟病毒基因鉴定进行了批判性回顾。
更新日期:2019-01-26
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