Mosquitoes are considered the most important vectors for the transmission of pathogens to humans. Aedes aegypti is a unique species, not only by its highly anthropophilic and peridomestic habits but also because it can transmit an important variety of pathogenic viruses. Examples are dengue, yellow fever, chikungunya, Zika, and Mayaro viruses. After ingesting viremic blood, a wide range of mechanisms are activated in the mosquito to counteract viral infection. Nevertheless, these arboviruses possess strategies to overcome barriers in the mosquito and eventually reach the salivary glands to continue the transmission cycle. However, the infection and eventual transmission of arbovirus depends on multiple factors. The current review focuses in detail on the anatomic, physiological, and molecular characteristics of the mosquito A. aegypti that participate in response to a viral infection. In the past decades, the awareness of the importance of this mosquito as a disease vector and its impact on human health was largely recognized. We need to improve our comprehension of molecular mechanisms that determine the outcome of successful virus replication or control of infection for each arbovirus in the vector; this could lead to the design of effective control strategies in the future.

中文翻译：

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埃及伊蚊（Aedes aegypti Mosquitoes）传播虫媒病毒的分子基础。

蚊子被认为是病原体向人类传播的最重要载体。埃及伊蚊是一种独特的物种，不仅因为其高度嗜人和腹围的习惯，而且还因为它可以传播多种重要的病原病毒。例子是登革热，黄热病，基孔肯雅热，寨卡病毒和玛雅罗病毒。摄入病毒性血液后，蚊子会激活多种机制来抵抗病毒感染。然而，这些虫媒病毒具有克服蚊子屏障并最终到达唾液腺以继续传播周期的策略。但是，虫媒病毒的感染和最终传播取决于多种因素。当前的审查集中在蚊子A的解剖，生理和分子特征上。埃及人，对病毒感染有反应。在过去的几十年中，人们普遍认识到这种蚊子作为一种疾病媒介的重要性及其对人类健康的影响。我们需要提高对分子机制的理解，这些分子机制决定了载体中每种虫媒病毒的成功病毒复制或感染控制的结果。这可能会导致将来设计有效的控制策略。