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Peptide-Assisted Design of Precision Polymer Sequences: On the Relevance of the Side-Chain Sequences and the Variability of the Backbone.
Macromolecular Bioscience ( IF 4.6 ) Pub Date : 2019-09-04 , DOI: 10.1002/mabi.201900244 Sensu Celasun 1 , Eva Maron 1 , Hans G Börner 1
Macromolecular Bioscience ( IF 4.6 ) Pub Date : 2019-09-04 , DOI: 10.1002/mabi.201900244 Sensu Celasun 1 , Eva Maron 1 , Hans G Börner 1
Affiliation
Functional sequences of monodisperse, sequence‐defined oligo(amide‐urethane)s are designed based on a peptide sequence as blueprint. The translation of a discrete side‐chain functionality sequence from a known peptide‐based solubilizer of the photosensitizer meta‐tetra(hydroxyphenyl)‐chlorin, into a non‐peptidic precision polymer backbone is demonstrated. The resulting peptidomimetic precision polymers retain the functions of the parent peptide sequence, showing analogues sensitivity toward single monomer mutations/exchanges and even exceeding the parent peptide equivalent by reaching up to 69% higher payload capacities and more favored release kinetics.
中文翻译:
精确聚合物序列的肽辅助设计:关于侧链序列的相关性和骨干的变异性。
基于肽序列作为蓝图设计了单分散,序列定义的低聚(酰胺-氨基甲酸酯)的功能序列。证明了将离散的侧链功能序列从光敏剂间四(羟苯基)-二氢卟酚的已知的基于肽的增溶剂转变为非肽的精密聚合物主链。所得的拟肽精密聚合物保留了母体肽序列的功能,显示出类似物对单个单体突变/交换的敏感性,甚至通过达到高达69%的更高有效负载能力和更有利的释放动力学,甚至超过了母体肽当量。
更新日期:2019-09-04
中文翻译:
精确聚合物序列的肽辅助设计:关于侧链序列的相关性和骨干的变异性。
基于肽序列作为蓝图设计了单分散,序列定义的低聚(酰胺-氨基甲酸酯)的功能序列。证明了将离散的侧链功能序列从光敏剂间四(羟苯基)-二氢卟酚的已知的基于肽的增溶剂转变为非肽的精密聚合物主链。所得的拟肽精密聚合物保留了母体肽序列的功能,显示出类似物对单个单体突变/交换的敏感性,甚至通过达到高达69%的更高有效负载能力和更有利的释放动力学,甚至超过了母体肽当量。