BACKGROUND The most common type of dementia is an Alzheimer's disease which is a major concern in growing chronic diseases in the geriatric society, and its connection with biochemistry has not been sufficiently understood. OBJECTIVE This study aims to evaluate the effects of blood biochemistry on Alzheimer's disease. METHOD Eight participants aged 55+ with Alzheimer's disease were analyzed. A cross-sectional work has conducted. Eighty patients have been divided into 2 groups as group A and group B according to laboratory findings including glycosylated hemoglobin, high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol (TC), triglycerides (TGA), vitamin D, folic acid, and vitamin B12. Mean Mini-Mental State Examination scores between these different 2 groups have been compared. RESULTS High levels of HDL, vitamin D, and folic acid correlate with cognitive scores, whereas high levels of total cholesterol, HbA1c, LDL show a negative effect on cognition scores. CONCLUSION High-density lipoprotein, vitamin D, folic acid, cholesterol, HgA1c, and LDL have an effect on dementia.

中文翻译：

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生化参数对阿尔茨海默氏病影响的研究。

背景技术痴呆最常见的类型是阿尔茨海默氏病，其是在老年社会中慢性病发展的主要关注点，并且其与生物化学的联系尚未得到足够的了解。目的本研究旨在评估血液生化对阿尔茨海默氏病的影响。方法对年龄在55岁以上且患有阿尔茨海默氏病的8位参与者进行分析。进行了横截面工作。80例患者根据实验室检查结果分为A组和B组，包括糖基化血红蛋白，高密度脂蛋白（HDL），低密度脂蛋白（LDL），总胆固醇（TC），甘油三酸酯（TGA），维生素D，叶酸和维生素B12。比较了这两组的平均小精神状态考试成绩。结果高水平的HDL，维生素D和叶酸与认知评分相关，而高水平的总胆固醇，HbA1c和LDL对认知评分产生负面影响。结论高密度脂蛋白，维生素D，叶酸，胆固醇，HgA1c和LDL对痴呆症有影响。