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Role of Macrophages in Pregnancy and Related Complications.
Archivum Immunologiae et Therapiae Experimentalis ( IF 3.2 ) Pub Date : 2019-07-08 , DOI: 10.1007/s00005-019-00552-7
Manoj K Jena 1, 2 , Neha Nayak 1 , Kang Chen 1 , Nihar R Nayak 1
Affiliation  

Macrophages (MФs) are the leukocytes produced from differentiation of monocytes and are located in almost all tissues of human body. They are involved in various processes, such as phagocytosis, innate and adaptive immunity, proinflammatory (M1) and anti-inflammatory (M2) activity, depending on the tissue microenvironment. They play a crucial role in pregnancy, and their dysfunction or alteration of polarity is involved in pregnancy disorders, like preeclampsia, recurrent spontaneous abortion, infertility, intrauterine growth restriction, and preterm labor. About 50-60% of decidual leukocytes are natural killer (NK) cells followed by MФs (the second largest population). MФs are actively involved in trophoblast invasion, tissue and vascular remodeling during early pregnancy, besides their role as major antigen-presenting cells in the decidua. These cells have different phenotypes and polarities in different stages of pregnancy. They have also been observed to enhance tumor growth by their anti-inflammatory activity (M2 type) and prevent immunogenic rejection. Targeted alteration of polarity (M1-M2 or vice versa) could be a major focus in the future treatment of pregnancy complications. This review is focused on the role of MФs in pregnancy, their involvement in pregnancy disorders, and decidual MФs as possible therapeutic targets for the treatment of pregnancy complications.

中文翻译:

巨噬细胞在妊娠及相关并发症中的作用。

巨噬细胞(MФs)是单核细胞分化产生的白细胞,位于人体几乎所有组织中。它们参与各种过程,例如吞噬作用,先天和适应性免疫,促炎(M1)和抗炎(M2)活性,具体取决于组织的微环境。它们在妊娠中起着至关重要的作用,其功能障碍或极性改变与妊娠疾病有关,例如先兆子痫,反复自然流产,不育,宫内生长受限和早产。蜕膜白细胞中约50-60%是自然杀伤(NK)细胞,其次是MФs(第二大种群)。MФ除了在蜕膜中作为主要的抗原呈递细胞外,还积极参与妊娠早期的滋养细胞侵袭,组织和血管重塑。这些细胞在怀孕的不同阶段具有不同的表型和极性。还已经观察到它们通过其抗炎活性(M2型)促进肿瘤生长并防止免疫原性排斥。极性的靶向改变(M1-M2,反之亦然)可能是未来妊娠并发症治疗的主要重点。这篇综述集中于MФs在妊娠中的作用,它们与妊娠疾病的关系以及蜕膜MФs作为治疗妊娠并发症的可能治疗靶标。极性的靶向改变(M1-M2,反之亦然)可能是未来妊娠并发症治疗的主要重点。这篇综述集中于MФs在妊娠中的作用,它们与妊娠疾病的关系以及蜕膜MФs作为治疗妊娠并发症的可能治疗靶标。极性的靶向改变(M1-M2,反之亦然)可能是未来妊娠并发症治疗的主要重点。这篇综述集中于MФs在妊娠中的作用,它们与妊娠疾病的关系以及蜕膜MФs作为治疗妊娠并发症的可能治疗靶标。
更新日期:2019-11-01
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