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Chemical constituents from Ginkgo biloba leaves and their cytotoxicity activity.
Journal of Natural Medicines ( IF 3.3 ) Pub Date : 2019-09-06 , DOI: 10.1007/s11418-019-01359-8
Penghua Shu 1 , Mengyuan Sun 1 , Junping Li 1 , Lingxiang Zhang 1 , Haichang Xu 1 , Yueyue Lou 1 , Zhiyu Ju 1 , Xialan Wei 2 , Wenming Wu 3 , Na Sun 1
Affiliation  

One novel neoligan glucoside, Ginkgoside B (1), and one new glucose ester, 6-O-(4-hydroxyhydrocinnamoyl)-d-glucopyranose (2), along with nine known compounds (311) were isolated from the ethanol extract of Ginkgo biloba leaves. Their structures were elucidated by combination of spectroscopic analyses and alkaline methanolysis. The absolute configuration of compound 1 was determined by single-crystal X-ray diffraction. All the isolated compounds were evaluated for their cytotoxicity activities, and compound 11 exhibited IC50 values of 36.20 and 58.95 μM against 5637 and HeLa cell lines, respectively.

中文翻译:

银杏叶的化学成分及其细胞毒性活性。

一个新颖neoligan葡糖苷,Ginkgoside B(1),以及一个新的葡萄糖酯,6- ø - (4-羟基氢化肉桂酰基) - d -glucopyranose(2),具有九个已知化合物(沿3 - 11)从乙醇提取物中分离的银杏叶。通过光谱分析和碱性甲醇解结合阐明了它们的结构。化合物1的绝对构型通过单晶X射线衍射测定。评价所有分离的化合物的细胞毒性活性,化合物11的IC 50值 分别针对5637和HeLa细胞系的36.20和58.95μM值。
更新日期:2019-09-06
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