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Mild Synthetic Approach to Novel Indole-1-Carbinols and Preliminary Evaluation of Their Cytotoxicity in Hepatocarcinoma Cells
Archiv der Pharmazie ( IF 5.1 ) Pub Date : 2011-10-28 , DOI: 10.1002/ardp.201100104
Gloria Zedda 1 , Gabriella Simbula , Michela Begala , Monica Pibiri , Costantino Floris , Mariano Casu , Laura Casu , Graziella Tocco
Affiliation  

A mild and versatile method for the synthesis of some novel indole‐1‐carbinols has been developed via one‐pot reaction of indoles and paraformaldehyde in the presence of an excess of CaO, MgO, ZnO or TiO2. The solvent‐free reaction provided all the indole derivatives in moderate to good yields and short reaction times. Moreover, the effect of some selected indole‐1‐carbinols on cell proliferation of the hepatoma cell line FaO was evaluated.

中文翻译:

新型 Indole-1-Carbinols 的温和合成方法及其在肝癌细胞中的细胞毒性的初步评价

在过量的 CaO、MgO、ZnO 或 TiO2 存在下,通过吲哚和多聚甲醛的一锅反应,开发了一种温和且通用的合成一些新型吲哚-1-甲醇的方法。无溶剂反应以中等至良好的产率和较短的反应时间提供了所有吲哚衍生物。此外,还评估了一些选定的 indole-1-carbinols 对肝癌细胞系 FaO 细胞增殖的影响。
更新日期:2011-10-28
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