Traumatic brain injury (TBI) is the most common cause of long-term disability and death among young adults, and it represents an enormous socioeconomic and healthcare burden. Our purpose is to evaluate the effects of a virtual reality training with BTs-Nirvana (BTs-N) on the recovery of cognitive functions in TBI subjects, using the interactive semi-immersive program. One hundred patients with TBI were enrolled in this study and randomized into either the Traditional Cognitive Rehabilitation Group (TCRG: ) or the Virtual Reality Training Group (VRTG: ). The VRTG underwent a VRT with BTs-N, whereas the TCRG received a standard cognitive treatment. Each treatment session lasted 60 minutes and was repeated three times a week for 8 weeks. All of the patients were evaluated by a specific psychometric battery before (T0) and immediately (T1) after the end of the training. VRTG and TCRG had a significant improvement in cognitive functioning and in mood, but only VRTG presented with a significant increase in cognitive flexibility and shifting skills and in selective attention. In conclusion, our results suggest that VR may be a useful and effective approach for the rehabilitation of patients with TBI, leading to better cognitive and behavioral outcomes.

中文翻译：

---

脑外伤后认知功能的改善：关于半身虚拟现实的潜在用途的临床试验。

外伤性脑损伤（TBI）是年轻人长期致残和死亡的最常见原因，它代表着巨大的社会经济和医疗负担。我们的目的是使用交互式半沉浸式程序评估使用BTs-涅磐（BTs-N）进行的虚拟现实训练对TBI受试者认知功能恢复的影响。这项研究招募了100名TBI患者，并随机分为传统认知康复小组（TCRG：）或虚拟现实培训小组（VRTG：）。VRTG用BTs-N进行了VRT，而TCRG接受了标准的认知治疗。每次治疗持续60分钟，每周重复3次，共8周。在训练结束前（T0）和训练结束后立即（T1），通过特定的心理测验对所有患者进行评估。VRTG和TCRG在认知功能和情绪上都有显着改善，但只有VRTG表现出认知灵活性和转移技能以及选择性注意显着提高。总之，我们的结果表明，VR可能是TBI患者康复的一种有用且有效的方法，可以带来更好的认知和行为结果。