Some 5‐fluoro‐6‐substitute‐1 H‐benzimidazole‐2‐carbamates (12a—e), 5‐fluoro‐6‐substituted 1 H‐benzimidazole‐2‐acetate (13a—e) and 2‐acetamide (14a—f) derivatives, 2‐acetamido‐5‐fluoro‐6‐(morpholin‐4‐yl)‐1‐propyl‐1 H‐benzimidazole (15), and 1‐cyclopropyl‐2‐ethyl‐5‐fluoro‐6‐(4‐methylpiperazin‐1‐yl)‐1 H‐benzimidazole (16) were synthesized, and their antimicrobial and antifungal activities evaluated. Compound 12c exhibited the best activity against Candida albicans.

中文翻译：

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5-氟-1,2,6-三取代苯并咪唑甲酰胺和乙酰胺衍生物的合成及抗菌活性

一些 5-氟-6-取代基-1 H-苯并咪唑-2-氨基甲酸酯 (12a-e)、5-氟-6-取代的 1 H-苯并咪唑-2-乙酸酯 (13a-e) 和 2-乙酰胺 (14a- f) 衍生物，2-乙酰氨基-5-氟-6-(吗啉-4-基)-1-丙基-1H-苯并咪唑(15)和1-环丙基-2-乙基-5-氟-6-(合成了 4-甲基哌嗪-1-基)-1 H-苯并咪唑 (16)，并评估了它们的抗菌和抗真菌活性。化合物12c对白色念珠菌表现出最好的活性。