Eleven chalcones were prepared and tested as antinociceptive agents using the writhing test in mice. Some compounds, given intraperitoneally, caused potent and dose‐related antinociception, being several times more active than some reference drugs. The results evidenced that some physico‐chemical parameters are involved in the pharmacological activity. 3,4‐Dichlorochalcone (2) was the most effective compound, and was also studied in another model of pain in mice, the formalin test. Here it inhibited only the inflammatory pain (second phase), being equipotent to the reference drugs.

中文翻译：

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查尔酮的镇痛特性。构效关系

制备了 11 种查耳酮，并使用小鼠扭体试验作为镇痛剂进行了测试。某些腹膜内给药的化合物可引起强效且与剂量相关的镇痛作用，其活性是某些参考药物的数倍。结果表明，一些理化参数与药理活性有关。3,4-二氯查耳酮 (2) 是最有效的化合物，也在另一种小鼠疼痛模型福尔马林试验中进行了研究。此处它仅抑制炎性疼痛（第二阶段），与参考药物等效。