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Genetic, epigenetic and biochemical regulation of succinate dehydrogenase function
Biological Chemistry ( IF 3.7 ) Pub Date : 2020-02-25 , DOI: 10.1515/hsz-2019-0264
Behrooz Moosavi 1 , Xiao-Lei Zhu 1 , Wen-Chao Yang 1 , Guang-Fu Yang 1
Affiliation  

Abstract Succinate dehydrogenase (SDH), complex II or succinate:quinone oxidoreductase (SQR) is a crucial enzyme involved in both the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS), the two primary metabolic pathways for generating ATP. Impaired function of SDH results in deleterious disorders from cancer to neurodegeneration. SDH function is tailored to meet the energy demands in different cell types. Thus, understanding how SDH function is regulated and how it operates in distinct cell types can support the development of therapeutic approaches against the diseases. In this article we discuss the molecular pathways which regulate SDH function and describe extra roles played by SDH in specific cell types.

中文翻译:

琥珀酸脱氢酶功能的遗传、表观遗传和生化调控

摘要 琥珀酸脱氢酶 (SDH),复合物 II 或琥珀酸:醌氧化还原酶 (SQR) 是参与三羧酸 (TCA) 循环和氧化磷酸化 (OXPHOS) 的关键酶,这是生成 ATP 的两个主要代谢途径。SDH 的功能受损会导致从癌症到神经变性的有害疾病。SDH 功能专为满足不同细胞类型的能量需求而定制。因此,了解 SDH 功能如何被调节以及它如何在不同的细胞类型中运作可以支持针对这些疾病的治疗方法的开发。在本文中,我们讨论调节 SDH 功能的分子途径,并描述 SDH 在特定细胞类型中发挥的额外作用。
更新日期:2020-02-25
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