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Dealing with death when studying disease or physiological marker: the stochastic system approach to causality.
Lifetime Data Analysis ( IF 1.3 ) Pub Date : 2018-11-17 , DOI: 10.1007/s10985-018-9454-3
Daniel Commenges 1
Affiliation  

The stochastic system approach to causality is applied to situations where the risk of death is not negligible. This approach grounds causality on physical laws, distinguishes system and observation and represents the system by multivariate stochastic processes. The particular role of death is highlighted, and it is shown that local influences must be defined on the random horizon of time of death. We particularly study the problem of estimating the effect of a factor V on a process of interest Y, taking death into account. We unify the cases where Y is a counting process (describing an event) and the case where Y is quantitative; we examine the case of observations in continuous and discrete time and we study the issue of whether the mechanism leading to incomplete data can be ignored. Finally, we give an example of a situation where we are interested in estimating the effect of a factor (blood pressure) on cognitive ability in elderly.

中文翻译:

在研究疾病或生理指标时处理死亡:采用随机系统方法处理因果关系。

因果关系的随机系统方法适用于死亡风险不可忽略的情况。这种方法将因果关系建立在物理定律的基础上,区分系统和观察,并通过多元随机过程表示系统。强调了死亡的特殊作用,并且表明必须在死亡时间的随机范围内定义局部影响。我们特别研究了在考虑到死亡的情况下估算因子V对感兴趣过程Y的影响的问题。我们将Y是计数过程(描述事件)的情况与Y是定量的 我们研究了连续不连续时间的观测情况,并研究了导致不完整数据的机制是否可以忽略的问题。最后,我们举一个例子,说明我们有兴趣估算一个因素(血压)对老年人认知能力的影响。
更新日期:2018-11-17
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