The aim of the present study was to evaluate the clinical effects and antioxidant potential of spray-dried yerba mate extract (SDME) capsules in healthy individuals. Fourteen healthy volunteers consumed three capsules of SDME three times daily. Measurements were carried out at the baseline and after 7, 30, and 60 days of SDME capsules intake. Electrocardiogram, hematological, urinary, and biochemical parameters analyzed remained within the normal values during all the study. SDME capsules ingestion increased significantly serum antioxidant capacity (after 7 and 30 days) and reduced glutathione values (after 7 and 60 days), and the superoxide dismutase (after 7, 30, and 60 days), catalase (after 7 and 30 days), and paraoxonase-1 activities (after 7 days); and decreased lipid hydroperoxides (after 30 and 60 days) and thiobarbituric acid reactive substances levels (after 7 and 30 days). No change was observed for glutathione peroxidase activity after SDME capsules intake. The present study showed that SDME capsules ingestion by healthy individuals did not promote clinical changes and promoted an increase of antioxidant biomarkers with a concomitant decrease of lipid peroxidation biomarkers in a short and prolonged manner.

中文翻译：

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喷雾干燥马黛茶提取物胶囊：健康个体的临床评估和抗氧化潜力

本研究的目的是评估喷雾干燥马黛茶提取物 (SDME) 胶囊对健康个体的临床效果和抗氧化潜力。14 名健康志愿者每天 3 次服用三粒 SDME。在基线和 SDME 胶囊摄入 7、30 和 60 天后进行测量。在所有研究期间，所分析的心电图、血液学、尿液和生化参数均保持在正常值内。SDME 胶囊摄入显着增加血清抗氧化能力（7 天和 30 天后）并降低谷胱甘肽值（7 天和 60 天后）以及超氧化物歧化酶（7、30 和 60 天后）、过氧化氢酶（7 天和 30 天后）和对氧磷酶 1 活性（7 天后）；降低脂质氢过氧化物（30 天和 60 天后）和硫代巴比妥酸活性物质水平（7 天和 30 天后）。摄入 SDME 胶囊后，未观察到谷胱甘肽过氧化物酶活性的变化。本研究表明，健康个体摄入 SDME 胶囊不会促进临床变化，而是促进抗氧化生物标志物的增加，同时脂质过氧化生物标志物在短期和长期内减少。