PURPOSE Incidence and mortality rates of uterine cancer are increasing and, obesity, which is also rising, has been associated with uterine cancer development and mortality. A recent study found that poor sleep quality is common among endometrial cancer survivors and those with obesity had more sleep disturbances than those having normal weight. However, it is unclear if higher levels of obesity (Class III, BMI ≥ 40 kg/m2), which are rising rapidly, are differentially associated with sleep as well as depression and quality of life in endometrial cancer survivors. METHODS We evaluated sleep, depression, and quality of life in 100 Stage I endometrial cancer survivors with obesity seeking weight loss enrolled in a lifestyle intervention (NCT01870947) at baseline. RESULTS The average age was 60 years and mean BMI was 42.1 kg/m2 with 58% having a BMI ≥ 40 kg/m2. Most survivors (72.3%) had poor sleep quality and most (71.2%) reported sleeping < 7 h/night. Survivors with class III compared with class I obesity had significantly more sleep disturbances and daytime dysfunction; and, those with poor sleep had higher depression and lower quality of life. Survivors with a BMI ≥ 50 kg/m2 (~ 25%) had the highest levels of depression and lowest physical and emotional well-being. CONCLUSIONS Our results reveal that endometrial cancer survivors with class III compared with class I obesity have poorer sleep quality, higher depression, and lower quality of life. Given the rising rates of obesity and uterine cancer mortality, interventions to combat both obesity and poor sleep are needed.

中文翻译：

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肥胖，寻求减肥的子宫内膜癌幸存者的睡眠，生活质量和抑郁感。

目的子宫癌的发病率和死亡率正在增加，并且肥胖症也在增加，与子宫癌的发展和死亡率有关。最近的一项研究发现，子宫内膜癌幸存者中常见的睡眠质量差，肥胖者的睡眠障碍要多于体重正常者。然而，尚不清楚子宫内膜癌幸存者的肥胖，睡眠水平，抑郁和生活质量是否存在差异，肥胖的升高水平（III类，BMI≥40 kg / m2）是否正在迅速上升。方法我们评估了基线时通过生活方式干预（NCT01870947）入组的100名肥胖寻求减肥的I期子宫内膜癌幸存者的睡眠，抑郁和生活质量。结果平均年龄为60岁，平均BMI为42。1 kg / m2，其中58％的BMI≥40 kg / m2。大多数幸存者（72.3％）的睡眠质量较差，大多数（71.2％）报告的睡眠时间<7小时/晚。与I类肥胖相比，III类幸存者的睡眠障碍和白天功能障碍明显更多。而且，睡眠不足的人抑郁更高，生活质量更低。BMI≥50 kg / m2（〜25％）的幸存者抑郁水平最高，身心健康最低。结论我们的研究结果表明，与I类肥胖相比，III类子宫内膜癌幸存者的睡眠质量较差，抑郁程度较高且生活质量较差。考虑到肥胖症和子宫癌死亡率的上升，需要采取干预措施来对抗肥胖症和睡眠不足。2％）报告的睡眠时间<7小时/晚。与I类肥胖相比，III类幸存者的睡眠障碍和白天功能障碍明显更多。而且，睡眠不足的人抑郁更高，生活质量更低。BMI≥50 kg / m2（〜25％）的幸存者抑郁水平最高，身心健康最低。结论我们的研究结果表明，与I类肥胖相比，III类子宫内膜癌幸存者的睡眠质量较差，抑郁程度较高且生活质量较差。考虑到肥胖症和子宫癌死亡率的上升，需要采取干预措施来对抗肥胖症和睡眠不足。2％）报告的睡眠时间<7小时/晚。与I类肥胖相比，III类幸存者的睡眠障碍和白天功能障碍明显更多。而且，睡眠不足的人抑郁更高，生活质量更低。BMI≥50 kg / m2（〜25％）的幸存者抑郁水平最高，身心健康最低。结论我们的研究结果表明，与I类肥胖相比，III类子宫内膜癌幸存者的睡眠质量较差，抑郁程度较高且生活质量较差。考虑到肥胖症和子宫癌死亡率的上升，需要采取干预措施来对抗肥胖症和睡眠不足。睡眠不良的人抑郁较高，生活质量较低。BMI≥50 kg / m2（〜25％）的幸存者抑郁水平最高，身心健康最低。结论我们的研究结果表明，与I类肥胖症相比，III类子宫内膜癌幸存者的睡眠质量较差，抑郁程度较高且生活质量较差。考虑到肥胖症和子宫癌死亡率的上升，需要采取干预措施来对抗肥胖症和睡眠不足。睡眠不良的人抑郁较高，生活质量较低。BMI≥50 kg / m2（〜25％）的幸存者抑郁水平最高，身心健康最低。结论我们的研究结果表明，与I类肥胖症相比，III类子宫内膜癌幸存者的睡眠质量较差，抑郁程度较高且生活质量较差。考虑到肥胖症和子宫癌死亡率的上升，需要采取干预措施来对抗肥胖症和睡眠不足。