OBJECTIVES Mucociliary clearance (MCC) is impaired due to chronic inflammation in allergic rhinitis. Our aim was to evaluate MCC in children with allergic rhinitis, to determine its relationship with disease severity and evaluate MCC change after nasal irrigation. MATERIALS AND METHODS Saccharin test was performed in 51 patients with allergic rhinitis and in 50 controls. Nasal irrigation was performed to the patients and saccharin test was repeated at the 10th minute. Total nasal symptom score (TNSS) and visual analogue scale (VAS) results were recorded. Patients were divided into mild/moderate-severe groups according to TNSS, VAS, and ARIA guidelines. Nasal MCC time (NMCCT) of the patients and the controls and NMCCT before and after nasal irrigation of the patients were compared. Correlations between NMCCT and TNSS/VAS were evaluated. NMCCTs of the mild and moderate-severe groups were compared. The cut-off values were calculated to discriminate the patient group. RESULTS The mean NMCCT of the patient group was higher than the controls. Mean NMCCTs were different between before and after irrigation. NMCCT was higher in uncontrolled/moderate-severe groups than in controlled/mild groups. NMCCT correlated positively with VAS and TNSS. The sensitivity and specificity of NMCCT>535s were found to be 86.27% and 94%, respectively. CONCLUSIONS In children with allergic rhinitis, the prolongation of MCC may be identified with the easily applicable saccharin test, the deterioration in MCC increases as disease severity increases. Nasal irrigation is important in children with allergic rhinitis to improve MCC.

中文翻译：

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过敏性鼻炎患儿鼻粘膜纤毛清除率与疾病严重程度的关系：一项比较横断面研究。

目的由于变应性鼻炎中的慢性炎症，粘膜纤毛清除（MCC）受到损害。我们的目的是评估变应性鼻炎患儿的MCC，确定其与疾病严重程度的关系，并评估鼻腔冲洗后MCC的变化。材料与方法对51例过敏性鼻炎患者和50例对照进行糖精试验。对患者进行鼻腔冲洗，并在第10分钟重复进行糖精试验。记录总鼻症状评分（TNSS）和视觉模拟量表（VAS）结果。根据TNSS，VAS和ARIA指南，将患者分为轻度/中度-重度组。比较患者的鼻MCC时间（NMCCT）和对照组以及患者鼻冲洗前后的NMCCT。评估了NMCCT与TNSS / VAS之间的相关性。比较了轻度和中度重度组的NMCCT。计算临界值以区分患者组。结果患者组的平均NMCCT高于对照组。灌溉前后的平均NMCCT不同。非对照/中度重度组的NMCCT高于对照/轻度组。NMCCT与VAS和TNSS正相关。NMCCT> 535s的敏感性和特异性分别为86.27％和94％。结论对于过敏性鼻炎患儿，MCC的延长可通过易于应用的糖精试验确定，随着疾病严重程度的增加，MCC的恶化也随之增加。鼻冲洗对于过敏性鼻炎患儿改善MCC至关重要。计算临界值以区分患者组。结果患者组的平均NMCCT高于对照组。灌溉前后的平均NMCCT不同。非对照/中度重度组的NMCCT高于对照/轻度组。NMCCT与VAS和TNSS正相关。NMCCT> 535s的敏感性和特异性分别为86.27％和94％。结论对于过敏性鼻炎患儿，MCC的延长可通过易于应用的糖精试验确定，随着疾病严重程度的增加，MCC的恶化也随之增加。鼻冲洗对于过敏性鼻炎患儿改善MCC至关重要。计算临界值以区分患者组。结果患者组的平均NMCCT高于对照组。灌溉前后的平均NMCCT不同。非对照/中度重度组的NMCCT高于对照/轻度组。NMCCT与VAS和TNSS正相关。NMCCT> 535s的敏感性和特异性分别为86.27％和94％。结论对于过敏性鼻炎患儿，MCC的延长可通过易于应用的糖精试验确定，随着疾病严重程度的增加，MCC的恶化也随之增加。鼻冲洗对于过敏性鼻炎患儿改善MCC至关重要。灌溉前后的平均NMCCT不同。非对照/中度重度组的NMCCT高于对照/轻度组。NMCCT与VAS和TNSS正相关。NMCCT> 535s的敏感性和特异性分别为86.27％和94％。结论对于过敏性鼻炎患儿，MCC的延长可通过易于应用的糖精试验确定，随着疾病严重程度的增加，MCC的恶化也随之增加。鼻冲洗对于过敏性鼻炎患儿改善MCC至关重要。灌溉前后的平均NMCCT不同。非对照/中度重度组的NMCCT高于对照/轻度组。NMCCT与VAS和TNSS正相关。NMCCT> 535s的敏感性和特异性分别为86.27％和94％。结论对于过敏性鼻炎患儿，MCC的延长可通过易于应用的糖精试验确定，随着疾病严重程度的增加，MCC的恶化也随之增加。鼻冲洗对于过敏性鼻炎患儿改善MCC至关重要。结论对于过敏性鼻炎患儿，MCC的延长可通过易于应用的糖精试验确定，随着疾病严重程度的增加，MCC的恶化也随之增加。鼻冲洗对于过敏性鼻炎患儿改善MCC至关重要。结论对于过敏性鼻炎患儿，MCC的延长可通过易于应用的糖精试验确定，随着疾病严重程度的增加，MCC的恶化也随之增加。鼻冲洗对于过敏性鼻炎患儿改善MCC至关重要。