Iron is one of the important trace elements in life activities. Abnormal iron metabolism increases the incidence of many skeletal diseases, especially for osteoporosis. Iron metabolism plays a key role in the bone homeostasis. Disturbance of iron metabolism not only promotes osteoclast differentiation and apoptosis of osteoblasts but also inhibits proliferation and differentiation of osteoblasts, which eventually destroys the balance of bone remodeling. The strength and density of bone can be weakened by the disordered iron metabolism, which increases the incidence of osteoporosis. Clinically, compounds or drugs that regulate iron metabolism are used for the treatment of osteoporosis. The goal of this review summarizes the new progress on the effect of iron overload or deficiency on osteoporosis and the mechanism of disordered iron metabolism on osteoporosis. Explaining the relationship of iron metabolism with osteoporosis may provide ideas for clinical treatment and development of new drugs.

中文翻译：

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铁代谢异常对骨质疏松症的影响。

铁是生活活动中重要的微量元素之一。铁代谢异常会增加许多骨骼疾病的发病率，尤其是骨质疏松症。铁代谢在骨稳态中起关键作用。铁代谢紊乱不仅促进成骨细胞的破骨细胞分化和凋亡，而且抑制成骨细胞的增殖和分化，最终破坏骨重塑的平衡。铁代谢紊乱会削弱骨骼的强度和密度，从而增加骨质疏松的发生率。临床上，调节铁代谢的化合物或药物用于治疗骨质疏松症。综述的目的总结了铁过剩或铁缺乏对骨质疏松症的影响以及铁代谢紊乱对骨质疏松症的作用的新进展。解释铁代谢与骨质疏松的关系可能为临床治疗和新药开发提供思路。