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In vivo mimicking model for solid tumor towards hydromechanics of tissue deformation and creation of necrosis
Journal of Biological Physics ( IF 1.8 ) Pub Date : 2018-05-28 , DOI: 10.1007/s10867-018-9496-5
Bibaswan Dey 1, 2 , G P Raja Sekhar 2 , Sourav Kanti Mukhopadhyay 3
Affiliation  

The present work addresses transvascular and interstitial fluid transport inside a solid tumor surrounded by normal tissue (close to an in vivo mimicking setup). In general, biological tissues behave like a soft porous material and show mechanical behavior towards the fluid motion through the interstitial space. In general, forces like viscous drag that are associated with the fluid flow may compress the tissue material. On the macroscopic level, we try to model the motion of fluids and macromolecules through the interstitial space of solid tumor and the normal tissue layer. The transvascular fluid transport is assumed to be governed by modified Starling’s law. The poroelastohydrodynamics (interstitial hydrodynamics and the deformation of tissue material) inside the tumor and normal tissue regions is modeled using linearized biphasic mixture theory. Correspondingly, the velocity distribution of fluid is coupled to the displacement field of the solid phase (mainly cellular phase and extracellular matrix) in both the normal and tumor tissue regions. The corresponding velocity field is used within the transport reaction equation for fluids and macromolecules through interstitial space to get the overall solute (e.g., nutrients, drug, and other macromolecules) distribution. This study justifies that the presence of the normal tissue layer plays a significant role in delaying/assisting necrosis inside the tumor tissue. It is observed that the exchange process of fluids and macromolecules across the interface of the tumor and normal tissue affects the effectiveness factor corresponding to the tumor tissue.

中文翻译:

实体瘤组织变形和坏死产生流体力学的体内模拟模型

目前的工作致力于解决被正常组织包围的实体瘤内部的经血管和间质液体运输(接近体内模拟设置)。一般来说,生物组织的行为类似于柔软的多孔材料,并且对通过间隙空间的流体运动表现出机械行为。一般而言,诸如与流体流动相关的粘性阻力的力可以压缩组织材料。在宏观层面上,我们尝试模拟流体和大分子通过实体瘤和正常组织层间隙的运动。假设跨血管流体输送受修正的斯塔林定律支配。使用线性双相混合理论对肿瘤和正常组织区域内的孔隙弹性流体动力学(间质流体动力学和组织材料的变形)进行建模。相应地,正常组织和肿瘤组织区域中流体的速度分布与固相(主要是细胞相和细胞外基质)的位移场耦合。相应的速度场用于流体和大分子通过间隙空间的传输反应方程,以获得总体溶质(例如,营养物、药物和其他大分子)分布。这项研究证明正常组织层的存在在延迟/协助肿瘤组织内部坏死方面发挥着重要作用。观察到肿瘤与正常组织界面上的液体和大分子的交换过程影响肿瘤组织对应的有效性因子。
更新日期:2018-05-28
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