The following sequences have been submitted to the Nomenclature Committee since the September 2018 nomenclature update Marsh (2018) and, following agreed policy, have been assigned official allele designations (Marsh et al., 2010). Full details of all sequences will be published in a forthcoming report. Below are listed the newly assigned sequences (Table 1) and con‐ firmations of previously reported sequences (Table 2). The accession number of each sequence is given, and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data librar‐ ies. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case, you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. An additional 664 (Lazaro et al., 2018) and 152 (Voorter et al., 2018) alleles were recently published but have not been included in Table 3 due to space considerations. In addition, after reviewing the recombination event which forms the alleles C*03:99:01 and C*03:99:02, they have been shown to belong to the C*01 allele group and have therefore been renamed as C*01:169:01 and C*01:169:02, respectively. C*04:01:01:30 has been shown to be identical to C*04:01:01:27. DQB1*03:325 was named in error and was shown to be a silent variant of DQB1*03:317; as a result, it has been re‐ named as DQB1*03:317:02. DPB1*793:01N was named in error and was shown to be a silent variant of DPB1*786:01N; as a result, it has been renamed as DPB1*786:01:02N. The names C*03:99:01, C*03:99:02, C*04:01:01:30, DQB1*03:325 and DPB1*793:01N have been abandoned. All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IPD‐IMGT/HLA Database using the sequence submission tool provided (Robinson et al., 2015). The IPD‐IMGT/ HLA Database may be accessed via the World Wide Web at: www. ebi.ac.uk/ipd/imgt/hla

中文翻译：

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HLA 系统因素的命名法，2018 年 10 月、11 月和 12 月更新

自 2018 年 9 月更新命名法 Marsh（2018 年）以来，以下序列已提交给命名法委员会，并根据商定的政策，分配了官方等位基因名称（Marsh 等人，2010 年）。所有序列的完整细节将在即将发布的报告中公布。下面列出了新分配的序列（表 1）和先前报告序列的确认（表 2）。给出了每个序列的登录号，这些可用于从 EMBL、GenBank 或 DDBJ 数据库中检索序列文件。尽管数据库已经分配了登录号并且大多数序列已经可用，但仍有可能作者尚未允许发布该序列；在这种情况下，您必须直接联系提交作者。有关新序列的附加信息通常包含在描述这些等位基因的出版物中；表 3 列出了描述新 HLA 序列的近期出版物。另外还有 664 个（Lazaro 等人，2018 年）和 152 个（Voorter 等人，2018 年）等位基因最近发表，但由于原因未包括在表 3 中以空间考虑。此外，在审查形成等位基因 C*03:99:01 和 C*03:99:02 的重组事件后，它们被证明属于 C*01 等位基因组，因此被重命名为 C*01 :169:01 和 C*01:169:02，分别。C*04:01:01:30 已被证明与 C*04:01:01:27 相同。DQB1*03:325 被错误命名并被证明是 DQB1*03:317 的无声变体；因此，它已被重命名为 DQB1*03:317:02。DPB1*793：01N 被错误命名并被证明是 DPB1*786:01N 的无声变体；因此，它已重命名为 DPB1*786:01:02N。名称 C*03:99:01、C*03:99:02、C*04:01:01:30、DQB1*03:325 和 DPB1*793:01N 已被放弃。现在，所有新的和验证性序列都应使用提供的序列提交工具通过 IPD-IMGT/HLA 数据库直接提交给 WHO HLA 系统因素命名委员会（Robinson 等，2015）。IPD-IMGT/HLA 数据库可通过万维网访问：www. ebi.ac.uk/ipd/imgt/hla 现在，所有新的和验证性序列都应使用提供的序列提交工具通过 IPD-IMGT/HLA 数据库直接提交给 WHO HLA 系统因素命名委员会（Robinson 等，2015）。IPD-IMGT/HLA 数据库可通过万维网访问：www. ebi.ac.uk/ipd/imgt/hla 现在，所有新的和验证性序列都应使用提供的序列提交工具通过 IPD-IMGT/HLA 数据库直接提交给 WHO HLA 系统因素命名委员会（Robinson 等，2015）。IPD-IMGT/HLA 数据库可通过万维网访问：www. ebi.ac.uk/ipd/imgt/hla