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Recent Patents, Formulation Techniques, Classification and Characterization of Liposomes.
Recent Patents on Nanotechnology ( IF 2 ) Pub Date : 2018-11-28 , DOI: 10.2174/1872210513666181127110413
Reena Sheoran 1 , Sukhbir Lal Khokra 1 , Viney Chawla 2 , Harish Dureja 3
Affiliation  

BACKGROUND During past decades, liposomes have emerged as efficient carriers for drugs, diagnostics, vaccines, nutrients and other bioactive agents. Liposomes, the spherical vesicles consisting of phospholipids bilayer have the ability to encapsulate both lipophilic and hydrophilic drugs. Extensive studies have been done in the past for investigating a number of drugs and genes for controlled release with liposomal formulation. Liposomes have also been investigated for their use in cancer treatment. Liposomes offer various advantages because of their biocompatible, biodegradable, nontoxic and non-immunogenic nature. METHODS Liposomes have cell-specific targeting with important applications in the fields of nanotechnology like cancer therapy, diagnosis, gene delivery, cosmetics, agriculture and in food technology. They are prepared by various methods like sonication method, ethanol injection method, lipid film hydration method, micro-emulsion method. CONCLUSION This review will provide an overview of classification, the various formulation methods, characterization, patented formulations and applications of liposomes with future prospects.

中文翻译:

最近的专利,配制技术,脂质体的分类和表征。

背景技术在过去的几十年中,脂质体已经成为药物,诊断剂,疫苗,营养物和其他生物活性剂的有效载体。脂质体是由磷脂双层构成的球形囊泡,具有包封亲脂性和亲水性药物的能力。过去已经进行了广泛的研究,以研究许多用于脂质体制剂控释的药物和基因。还研究了脂质体在癌症治疗中的用途。脂质体具有生物相容性,可生物降解,无毒和非免疫原性的性质,因此具有多种优势。方法脂质体具有针对细胞的靶向性,在纳米技术领域如癌症治疗,诊断,基因传递,化妆品,农业和食品技术中具有重要应用。它们通过多种方法制备,例如超声处理法,乙醇注射法,脂质膜水合法,微乳化法。结论本综述将概述脂质体的分类,各种制剂方法,表征,专利制剂以及脂质体的应用,并具有未来的前景。
更新日期:2019-11-01
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