Here, a direct adaptive control strategy with parametric compensation is adopted for an uncertain non-linear model representing blood glucose regulation in type 1 diabetes mellitus patients. The uncertain parameters of the model are updated by appropriate design of adaptation laws using the Lyapunov method. The closed-loop response of the plasma glucose concentration as well as external insulin infusion rate is analysed for a wide range of variation of the model parameters through extensive simulation studies. The result indicates that the proposed adaptive control scheme avoids severe hypoglycaemia and gives satisfactory performance under parametric uncertainty highlighting its ability to address the issue of inter-patient variability.

中文翻译：

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1 型糖尿病患者的血糖调节：一种基于自适应参数补偿控制的方法。

在这里，对于表示 1 型糖尿病患者血糖调节的不确定非线性模型，采用了具有参数补偿的直接自适应控制策略。通过使用 Lyapunov 方法适当设计适应律来更新模型的不确定参数。通过广泛的模拟研究分析了血浆葡萄糖浓度的闭环响应以及外部胰岛素输注速率，以了解模型参数的广泛变化。结果表明，所提出的自适应控制方案避免了严重的低血糖症，并在参数不确定性下提供了令人满意的性能，突出了其解决患者间变异性问题的能力。