Abstract

This work represents one part of our research project, in which we attempted to prove that a humoral regulation between noradrenaline-producing organs exist in the perinatal period. In this study, we used a rat model that allowed blocking the synthesis of noradrenalin in the brain and evaluated gene expression and protein levels of noradrenaline key synthesis enzymes such as tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) in peripheral noradrenaline-producing organs. As a result, we showed an increased gene expression of TH and DBH in adrenal glands. These data indicate that, if neonatal rat brain lacks the ability to produce noradrenaline, then the synthesis of noradrenaline in adrenal glands increased as a compensatory process, so that the concentration levels in blood are maintained at normal levels. This indicates that there is a humoral regulation between brain and adrenal glands, which is not fully understood yet.

中文翻译：

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在形态发生过程中，大脑在调节大鼠周围产生去甲肾上腺素的器官中的作用。

摘要

这项工作是我们研究项目的一部分，其中我们试图证明围产期存在去甲肾上腺素的器官之间存在体液调节。在这项研究中，我们使用了一种大鼠模型，该模型可以阻止大脑中去甲肾上腺素的合成，并评估外周去甲肾上腺素-中去甲肾上腺素关键合成酶（例如酪氨酸羟化酶（TH）和多巴胺β-羟化酶（DBH））的基因表达和蛋白质水平生产器官。结果，我们显示了肾上腺中TH和DBH的基因表达增加。这些数据表明，如果新生大鼠的大脑缺乏产生去甲肾上腺素的能力，那么肾上腺中去甲肾上腺素的合成会作为一种补偿过程而增加，从而使血液中的浓度水平保持在正常水平。