Abstract

In this work, we investigated the NAD(P)-dependent dehydrogenase activity in different fields of the solid form of Ehrlich carcinoma. It was shown that there is a metabolic distinction between different fields of the solid tumor. In this way, there is a significant difference between the ascites and solid type of Ehrlich carcinoma. In the central area of the tested sample of tumor tissue, there is a high intensity of energetic metabolism and biosynthetic processes as opposed to the peripheral areas. Previously, we proposed the concept of nonspecific metabolic reaction of the cell in organism upon the influence of negative factors. In accordance with this concept, our results indicate the development of adaptation in the tumor cells in the central area of the tested sample.

中文翻译：

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实体型Enrlich癌的空间代谢异质性。

摘要

在这项工作中，我们调查了艾氏癌固体形式的不同领域中NAD（P）依赖的脱氢酶活性。结果表明，实体瘤的不同部位之间存在代谢区别。这样，在腹水和艾氏癌的实体类型之间存在显着差异。在测试的肿瘤组织样本的中心区域，与周围区域相比，能量代谢和生物合成过程的强度很高。以前，我们提出了在负面因素影响下生物体内细胞的非特异性代谢反应的概念。根据这个概念，我们的结果表明在被测样品中心区域的肿瘤细胞中适应性的发展。