Abstract

Using transgenic Drosophila model systems, we showed that four binding sites for the architectural protein dCTCF per se cannot form an effective insulator that blocks enhancers and protects against the Polycomb-dependent repression. These results suggest that, in the known Drosophila insulators, the dCTCF protein functions in cooperation with other architectural proteins.

中文翻译：

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在果蝇模型系统中研究dCTCF绝缘子的活性。

摘要

使用转基因果蝇模型系统，我们表明建筑蛋白dCTCF的四个结合位点本身无法形成有效的绝缘子，该绝缘子会阻断增强子并保护其免受Polycomb依赖性阻抑。这些结果表明，在已知的果蝇绝缘子中，dCTCF蛋白与其他结构蛋白协同作用。