Lipid rafts are organized plasma membrane microdomains, which provide a distinct level of regulation of cellular metabolism and response to extracellular stimuli, affecting a diverse range of physiologic and pathologic processes. This Thematic Review Series focuses on Biology of Lipid Rafts rather than on their composition or structure. The aim is to provide an overview of ideas on how lipid rafts are involved in regulation of different pathways and how they interact with other layers of metabolic regulation. Articles in the series will review the involvement of lipid rafts in regulation of hematopoiesis, production of extracellular vesicles, host interaction with infection, and the development and progression of cancer, neuroinflammation, and neurodegeneration, as well as the current outlook on therapeutic targeting of lipid rafts.

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脂质筏的生物学：专题综述系列简介。

脂质筏是有组织的质膜微区，可提供不同水平的细胞代谢调节和对细胞外刺激的反应，影响多种生理和病理过程。本专题综述系列关注脂质筏的生物学，而不是其组成或结构。目的是概述脂质筏如何参与不同途径的调控，以及它们如何与其他代谢调控层相互作用。该系列的文章将回顾脂质筏在调节造血，细胞外囊泡的产生，宿主与感染的相互作用以及癌症，神经炎症和神经退行性疾病的发展和进程中的作用，以及对脂质靶向治疗的当前前景木筏。