Liver inflammation and necrosis are the foremost problems interlinked with diabetes mellitus (DM). The methanolic extract of Sargassum muticum (MESM) plays a hepatoprotective role in streptozotocin- (STZ-) induced hepatic injury. In this study, STZ exposure induced diabetes that augmented hepatic damage, which was reflected in serum enzyme markers, the cytokine network, and caspase-3 and caspase-9 levels in Group 2. Exposure to the MESM tremendously modulated the levels of hepatic enzyme markers ALP, ACP, ALT, and AST in Groups 3 and 4. The cytokine network was well regulated by suppressing the release of cytokines, and the levels of caspase-3 and caspase-9 were also reduced in Groups 3 and 4. The present study suggests that MESM treatment at 200 and 500 mg protected the liver and also minimizes the glucose level. Thus, the MESM plays a key role in rejuvenating the liver and can modulate diabetes’s pathogenic effect by reducing the glucose level.

中文翻译：

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鼠尾草对Wistar大鼠STZ诱导的糖尿病性肝损伤的保护作用可能是通过抑制细胞因子和细胞凋亡途径实现的。

肝炎和坏死是与糖尿病（DM）相关的最主要问题。羊栖菜的甲醇提取物（MESM）在链脲佐菌素（STZ-）诱导的肝损伤中起肝保护作用。在这项研究中，STZ暴露诱导的糖尿病加剧了肝损害，这反映在第2组的血清酶标志物，细胞因子网络以及caspase-3和caspase-9水平上。暴露于MESM极大地调节了肝酶标志物的水平。第3和第4组中的ALP，ACP，ALT和AST。通过抑制细胞因子的释放，可以很好地调节细胞因子网络，在第3和第4组中，caspase-3和caspase-9的水平也降低了。提示200和500 mg的MESM治疗可以保护肝脏，并使葡萄糖水平降至最低。因此，MESM在振兴肝脏中起关键作用，并可以通过降低葡萄糖水平来调节糖尿病的致病作用。