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Risk and protective effects of serotonin and BDNF genes on stress-related adult psychiatric symptoms.
Neurobiology of Stress ( IF 5 ) Pub Date : 2019-07-26 , DOI: 10.1016/j.ynstr.2019.100186
Paul G Nestor 1 , Keira O'Donovan 1 , Hannah E Lapp 1 , Victoria Choate Hasler 1 , Sara B Boodai 1 , Richard Hunter 1
Affiliation  

We focused on individual risk by examining childhood adversity and current psychiatric symptoms in a sample of 100 college students genotyped for both the serotonin transporter (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF). Naturally occurring allelic variation in 5-HTTLPR (short/long) and BDNF (valine/methionine) have been strongly implicated in stress-related psychiatric risk, but the combined effects of these alleles on psychological functioning have yet to be fully elucidated. Univariate analysis revealed gene-environment correlations linking heightened psychiatric risk with past childhood adversity for short but not long 5-HTTLPR allelic carriers and for valine (Val) but not methionine (Met) BDNF allelic carriers. Multivariate analyses revealed a significant gene x gene interaction with results showing that risk varied systematically depending on both 5-HTTLPR and BDNF alleles, independent of childhood adversity. Hierarchical regression analyses indicated that approximately 11% of the variance in symptoms of depression could be specifically accounted for by the epistatic interaction of 5-HTTLPR and BDNF val66Met polymorphisms. Allelic group analyses indicated lowest risk, as measured by depression and anxiety, for allelic carriers of 5-HTTLPR-short and BDNF Met, followed by 5-HTTLPR-long and BDNF-Val, 5-HTTLPR-short and BDNF-Val, and 5-HTTLPR-long and BDNF-Met. Results suggest that protective or risk-enhancing effects on stress-related psychiatric functioning may depend on specific allelic combinations of 5-HTTLPR and BDNF.



中文翻译:

血清素和BDNF基因对与压力有关的成人精神症状的风险和保护作用。

我们通过检查100名大学生血清素转运蛋白(5-HTTLPR)和脑源性神经营养因子(BDNF)基因型的样本,研究了儿童期的逆境和当前的精神病症状,从而关注了个人风险。5-HTTLPR(短/长)和BDNF(缬氨酸/蛋氨酸)中自然发生的等位基因变异与应激相关的精神病风险密切相关,但这些等位基因对心理功能的综合影响尚未完全阐明。单因素分析显示,短而长的​​5-HTTLPR等位基因携带者和缬氨酸(Val)而不是蛋氨酸(Met)BDNF等位基因携带者的基因-环境相关性将较高的精神病风险与儿童过去的逆境联系在一起。多变量分析揭示了显着的基因x基因相互作用,结果表明,风险有系统地取决于5-HTTLPR和BDNF等位基因,与儿童时期的逆境无关。分层回归分析表明,抑郁症症状中约11%的差异可以由5-HTTLPR和BDNF val66Met多态性的上位性相互作用具体解释。等位基因组分析显示,通过抑郁和焦虑测得的5-HTTLPR-short和BDNF Met等位基因携带者风险最低,其次是5-HTTLPR-long和BDNF-Val,5-HTTLPR-short和BDNF-Val,以及5-HTTLPR长和BDNF-Met。结果表明,对应激相关的精神功能的保护作用或风险增强作用可能取决于5-HTTLPR和BDNF的特定等位基因组合。

更新日期:2019-07-26
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