Key role of the REC lobe during CRISPR–Cas9 activation by ‘sensing’, ‘regulating’, and ‘locking’ the catalytic HNH domain,Quarterly Reviews of Biophysics

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Key role of the REC lobe during CRISPR–Cas9 activation by ‘sensing’, ‘regulating’, and ‘locking’ the catalytic HNH domain
Quarterly Reviews of Biophysics ( IF 6.1 ) Pub Date : 2018-08-05 , DOI: 10.1017/s0033583518000070
Giulia Palermo ₁ , Janice S Chen ₂ , Clarisse G Ricci _{3,

4} , Ivan Rivalta ₅ , Martin Jinek ₆ , Victor S Batista ₇ , Jennifer A Doudna _{2,

8,

9,

10} , J Andrew McCammon _{3,

4,

11,

12}

Affiliation

Department of Bioengineering, University of California, Riverside, CA 92507.
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.
Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.
Université de Lyon, École Normale Supérieure (ENS) de Lyon, CNRS, Lyon 1, France.
Department of Biochemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.
Department of Chemistry, Yale University, P.O. Box 208107, New Haven, CT 06520-8107, USA.
Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Physical Biosciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, Berkeley, CA 94720, USA.
National Biomedical Computation Resource, University of California, San Diego, La Jolla, CA 92093, USA.
San Diego Supercomputer Center, University of California, San Diego, La Jolla, CA 92093, USA.